PMID: 8968037Dec 1, 1996Paper

Acquired osteosclerosis associated with intravenous drug use and hepatitis C infection

Bone
T Diamond, B Depczynski

Abstract

Hepatitis C has recently been recognized as a secondary cause of osteosclerosis; a further example, the first outside of North America, is described. A 37-year-old man with a history of intravenous drug use and known to be hepatitis C antibody positive presented with bone pain. Radiographs and magnetic resonance imaging demonstrated an increase in cortical and trabecular bone that on biopsy was of a normal lamellar pattern but markedly sclerotic. Biochemical markers of bone formation (serum osteocalcin) and resorption (urinary hydroxyproline excretion rate) were both markedly elevated. Pain lessened following administration of pamidronate. Biochemical markers of bone turnover fell towards their reference ranges 12 months after initiating pamidronate therapy but without significant change in bone mineral density. Osteosclerosis is a rare complication of hepatitis C infection, the symptoms of which are controllable with diphosphonate therapy.

References

Feb 1, 1992·The Journal of Endocrinology·M Hewison
Dec 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H S BeyerH Heath
Jan 1, 1982·Metabolism: Clinical and Experimental·E ManzkeD J Baylink
Jul 1, 1994·Journal of Hepatology·P BonettiA Alberti
Apr 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M PawlotskyJ Duval
Dec 1, 1993·The American Journal of Medicine·H S BeyerH Heath
Jun 1, 1993·Journal of Medical Virology·E J CartwrightP T Sharpe
Aug 1, 1995·Australian and New Zealand Journal of Medicine·B C SmithP V Desmond
Apr 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M P WhyteW R Reinus

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Citations

Jun 29, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C E FioreP Pennisi
Dec 8, 2004·Clinical Rheumatology·Paolo ManganelliMario Pedrazzoni
Jul 1, 1997·The American Journal of Medicine·A A HassounS Khosla
Feb 1, 1997·The American Journal of Medicine·M P Whyte, C A Reasner
Jul 3, 1998·Gastroenterology Clinics of North America·E W Lipkin
Aug 7, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Cheryl A ConoverSundeep Khosla
Aug 9, 2003·Journal of Biomaterials Science. Polymer Edition·Zhong ZhengGuo-Qiang Chen
May 24, 2006·Endocrine Journal·Tokuji TanakaJun Hashimoto
Apr 11, 2014·Skeletal Radiology·Narendranath Epperla, Fergus E McKiernan
Apr 19, 2011·Joint, Bone, Spine : Revue Du Rhumatisme·Rose-Marie JavierJean Sibilia
Jun 30, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Kavinderjit S NandaJohn E Hegarty
Mar 12, 2005·Arquivos brasileiros de endocrinologia e metabologia·Rodrigo O MoreiraMaria Lucia F Farias

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