Acquired resistance against a secondary infection with Listeria monocytogenes in mice is not dependent on reactive nitrogen intermediates.

Infection and Immunity
J N SamsomR van Furth

Abstract

During an infection, inflammatory mediators can induce the production of nitric oxide, a reactive nitrogen intermediate (RNI) which plays a role in antimicrobial activity against a wide variety of pathogens. In vitro experiments have shown that release of RNI by macrophages is mediated by tumor necrosis factor alpha (TNF). Since TNF is essential for acquired resistance during a secondary Listeria monocytogenes infection in mice, the aim of the present study was to determine whether RNI are also involved in the course of such an infection. Mice which had recovered from a sublethal primary infection with 0.1 50% lethal dose of (LD50) L. monocytogenes were infected intravenously with 10LD50 of L. monocytogenes. During a primary infection, the number of bacteria in the liver and spleen, as well as the concentration of RNI in plasma, increased. During a secondary infection, the number of bacteria in the liver and spleen decreased whereas no significant increase in the concentration of RNI in plasma was observed. Neutralization of endogenously produced TNF and gamma interferon by subcutaneous injection of alginate-encapsulated monoclonal antibody-forming cells during a secondary infection resulted in an increase in the number of bact...Continue Reading

References

Nov 1, 1989·The Journal of Experimental Medicine·R D CurranR L Simmons
Dec 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·A MülschR Busse
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R IyengarM A Marletta
Mar 1, 1994·Infection and Immunity·K S BoockvarR L Kurlander
Apr 15, 1994·Journal of Immunological Methods·H F SavelkoulA van Oudenaren
Jul 1, 1993·Infection and Immunity·P S HiemstraR I Lehrer
Jan 1, 1995·Scandinavian Journal of Infectious Diseases·P H GroeneveldJ Clement
Sep 1, 1962·The Journal of Experimental Medicine·G B MACKANESS

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Citations

May 12, 2001·Infection and Immunity·K A RemerS L Leib
Aug 19, 2007·The Journal of Experimental Medicine·Emilie Narni-MancinelliGrégoire Lauvau
Mar 18, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·G R RossiD T Masih
May 28, 2019·Microbiology Spectrum·Sarah E F D'Orazio

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