PMID: 6110472Dec 1, 1980Paper

Acquired transient CNS hypersensitivity to lithium therapy

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
A M Ghadirian, H E Lehmann

Abstract

Organic brain syndrome is reported to occur occasionally in patients who are treated with lithium carbonate alone, or in combination with neuroleptics. Such neurotoxicity is often associated with moderate to low serum lithium levels and is usually reversible upon the cessation of lithium treatment. The authors report on a 57 year old manic-depressive and alcoholic patient who, after four years of lithium treatment, developed symptoms of CNS hypersensitivity which reappeared several times when he was challenged with lithium during a two month period. The possible role of an underlying, subclinical encephalopathy, caused by episodic drinking, is considered.

References

Jul 1, 1979·The American Journal of Psychiatry·A P West, H Y Meltzer
Mar 1, 1976·The Australian and New Zealand Journal of Psychiatry·G F Johnson
May 1, 1973·Comprehensive Psychiatry·A RifkinF Quitkin
Oct 1, 1970·The Journal of Nervous and Mental Disease·G JohnsonJ Korein
Nov 1, 1972·The American Journal of Psychiatry·P L AgulnikP Moore
Feb 20, 1954·The Medical Journal of Australia·B GLESINGER

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Citations

May 18, 2007·The International Journal of Neuropsychopharmacology·Konstantinos N FountoulakisHagop Akiskal

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