Acquired vitamin K-dependent carboxylation deficiency in liver disease

The New England Journal of Medicine
R A BlanchardB Furie

Abstract

gamma-Carboxyglutamic acid residues on prothrombin are synthesized from glutamic acid on a prothrombin precursor in the liver through a vitamin K-dependent carboxylase. In the absence of vitamin K or in the presence of vitamin K antagonists, an inert form of prothrombin - abnormal prothrombin - circulates in the blood. We have developed specific immunoassays for native and abnormal human prothrombin. The prothrombin concentration in our normal subjects was 108 +/- 19 microgram per milliliter. The abnormal-prothrombin concentration varied over four orders of magnitude between the limits of detection in normal plasma and the level in patients with cirrhosis (0 to 5 microgram per milliliter), acute hepatitis (0 to 33 microgram per milliliter), or vitamin K deficiency (32 to 100 microgram per milliliter) and in those treated with sodium warfarin (12 to 65 microgram per milliliter). These studies indicate that abnormal prothrombin is not a component of normal plasma but appears in a variety of hepatic and nutritional disorders characterized by impaired hepatic vitamin-K-dependent carboxylation.

References

Feb 22, 1977·Biochimica Et Biophysica Acta·M P Esnouf, C V Prowse
Oct 1, 1979·The Journal of Clinical Investigation·D S FairT S Edgington
Jan 1, 1977·Annual Review of Biochemistry·J Stenflo, J W Suttie
Dec 25, 1979·Biochemistry·P M TuhyK G Mann
Jan 1, 1978·American Journal of Hematology·G D LoxJ J Corrigan
Sep 27, 1977·Biochimica Et Biophysica Acta·P A FriedmanA Fitz-James
May 20, 1976·Biochimica Et Biophysica Acta·C V ProwseA M Russell
Jan 4, 1973·Biochemical and Biophysical Research Communications·J Stenflo, P O Ganrot
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·J E Niléhn, P O Ganrot
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·P O Ganrot, J E Niléhn
Aug 25, 1974·FEBS Letters·S MagnussonA Dell
Jul 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J StenfloP Roepstorff
Jan 1, 1971·The Journal of Clinical Investigation·T S ZimmermanA S Littell
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·P O Ganrot, J E Niléhn
Jul 1, 1969·The Journal of Clinical Investigation·S S Shapiro, J Martinez
Jul 17, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·R M BertinaJ J Veltkamp

❮ Previous
Next ❯

Citations

Sep 25, 1981·Molecular and Cellular Biochemistry·J P BurnierB Furie
May 1, 1989·The Japanese Journal of Surgery·Y Kawaguchi
Jun 18, 2010·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Rui YangYu Hu
Nov 11, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·S UeharaA Hirayama
May 1, 1987·Mayo Clinic Proceedings·G Colon-OteroE J Bowie
May 23, 2001·Thrombosis Research·M Koldas, F Uras
Jul 20, 2002·Journal of Hepatology·Ton LismanPhilip G de Groot
Nov 25, 2004·Clinics in Liver Disease·K V Kowdley
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·A SweattR Wallin
Nov 19, 1981·The New England Journal of Medicine·D L Earnest, J J Corrigan
May 31, 1984·The New England Journal of Medicine·H A LiebmanB Furie
Mar 19, 1992·The New England Journal of Medicine·B Furie, B C Furie
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H A LiebmanB Furie
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D L DiuguidB Furie
Jun 1, 1990·British Journal of Haematology·M J Shearer
Aug 1, 1990·British Journal of Haematology·B BrennerU Seligsohn
Apr 30, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·T SuehiroC M Miller
Sep 22, 2005·Journal of Gastroenterology and Hepatology·Soichiro UeharaMitiko Senshuu
Apr 30, 1998·Journal of Veterinary Internal Medicine·S C LisciandroM Brooks
Mar 1, 1986·Gut·D A Kelly, E G Tuddenham
Jun 1, 1994·Journal of Clinical Pathology·S A OmranS M Toiema
Nov 1, 1981·The Journal of Clinical Investigation·J H GriffinC Wideman
Jun 1, 1982·The Journal of Clinical Investigation·G H GoldsmithB Furie
Jul 16, 2014·Nature Reviews. Gastroenterology & Hepatology·Neeral L ShahStephen H Caldwell
Nov 8, 2014·Blood·Sol Schulman, Bruce Furie
Jan 1, 1997·Cancer Investigation·S J Kempin
Jan 20, 2009·Clinics in Liver Disease·Greg G C HugenholtzTon Lisman
Aug 4, 2011·Journal of Thrombosis and Haemostasis : JTH·H SaitoT Kojima
Dec 15, 1984·Thrombosis Research·C BoyerM J Larrieu
Aug 15, 1984·Thrombosis Research·D V ShahJ W Suttie
Sep 1, 1987·Thrombosis Research·O P Malhotra, O Sudilovsky
Oct 15, 1991·Thrombosis Research·B Kemkes-MatthesK J Matthes
Feb 1, 1993·Journal of Pediatric Surgery·A NajmaldinJ D Atwell
Mar 1, 1985·The Journal of Pediatrics·P A Lane, W E Hathaway
Jul 5, 2005·Critical Care Clinics·Jody L Kujovich
Dec 1, 1987·Midwifery·M A Hall, P Pairaudeau

❮ Previous
Next ❯

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