Acquired VLDL receptor deficiency in experimental nephrosis

Kidney International
K Liang, Nosratola D Vaziri

Abstract

Nephrotic syndrome (NS) is commonly associated with elevation of plasma very low density lipoprotein (VLDL) and triglyceride concentrations. VLDL receptor (VLDL-R) is a novel protein that specifically binds and internalizes VLDL particles and is primarily distributed in heart, skeletal muscle, brain and adipose tissue. Based on these properties, VLDL-R is thought to play a role in VLDL and triglyceride metabolism. The present study was undertaken to test the hypothesis that elevation of plasma VLDL in NS may be, in part, related to VLDL-R deficiency. To this end, heart and skeletal muscle VLDL-R protein (Western blot) and mRNA (Northern blot) were measured at various points in the course of puromycin-induced NS in rats. The results were compared with those obtained in the placebo-treated normal control animals. The NS group showed a significant decline in VLDL-R protein (relative to total plasma membrane protein mass) in the heart and skeletal muscle paralleling the rise in plasma VLDL and triglyceride concentrations. The fall in VLDL-R protein was accompanied by a parallel decline in VLDL-R mRNA in the heart but not skeletal muscle. VLDL-R protein was directly related to proteinuria and inversely related to plasma VLDL and tri...Continue Reading

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Citations

Feb 16, 1999·Biochimica Et Biophysica Acta·N D VaziriC H Barton
Jul 21, 1999·Kidney International. Supplement·G A Kaysen, M G de Sain-van der Velden
Jan 12, 2002·Kidney International·Tadashi SatoNosratola D Vaziri
Apr 23, 2002·Kidney International·Nosratola D Vaziri, Kaihui Liang
Apr 5, 2003·Kidney International·Nosratola D Vaziri
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Mar 1, 1997·Kidney International·N D Vaziri, K Liang
Jun 1, 1997·Kidney International·K Liang, N D Vaziri
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