Acquired von Willebrand disease secondary to hypothyroidism: a rare cause for postextraction hemorrhage

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
John M Hanratty, C G Cowan

Abstract

Acquired von Willebrand's Disease (AvWD) is a rare disease with a clinical pattern similar to the congenital disorder that typically presents later in life in patients with no prior history of prolonged bleeding. It has been shown to be related to a number of common medical conditions including lymphoproliferative and myeloproliferative diseases, cardiovascular disease, immunological disorders, neoplasia, drugs, and miscellaneous disorders. We present 2 cases where post- and interoperative hemorrhage were the initial sign of AvWD and a previously undiagnosed hypothyroid condition was the precipitating factor. There are no similar cases reported within the dental literature. We highlight the importance of taking a medical history and bleeding history in all patients about to undergo oral surgery, periodontal surgery, or implant placement. Increased vigilance is suggested when patients, who have been otherwise well, present with abnormal bleeding problems as this may be a manifestation of an underlying undiagnosed disease.

References

Oct 1, 1995·Thyroid : Official Journal of the American Thyroid Association·L A AttivissimoI Klein
Jun 27, 1998·The British Journal of Oral & Maxillofacial Surgery·J T Wilde, R J Cook
Dec 3, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·I C Nitu-Whalley, C A Lee
Oct 31, 2001·Clinical and Laboratory Haematology·S Keeney, A M Cumming
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Jul 11, 2006·American Journal of Hematology·Hiroshi Mohri
Jan 26, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·E ManfrediA Squizzato

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Citations

Mar 30, 2013·Forensic Science International : Synergy·Wataru KawashimaAkiko Ishitani
Nov 23, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·S HassanP Kuriakose

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