Acquired von Willebrand Syndrome in Patients With Ventricular Assist Device

Frontiers in Medicine
Antoine RauchBarbara Zieger

Abstract

During the last decade the use of ventricular assist devices (VADs) for patients with severe heart failure has increased tremendously. However, flow disturbances, mainly high shear induced by the device is associated with bleeding complications. Shear stress-induced changes in VWF conformation are associated with a loss of high molecular weight multimers (HMW) of VWF and an increased risk of bleeding. This phenomenon and its cause will be elaborated and reviewed in the following.

References

Nov 25, 1997·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·O DewaldB Reichart
Dec 3, 2005·Blood·Wolf Achim HassenpflugReinhard Schneppenheim
May 2, 2007·Proceedings of the National Academy of Sciences of the United States of America·S W SchneiderM F Schneider
Nov 21, 2007·The Journal of Thoracic and Cardiovascular Surgery·Michael MarklFriedhelm Beyersdorf
Feb 20, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Ulrich GeisenBarbara Zieger
Jan 22, 2009·The Journal of Thoracic and Cardiovascular Surgery·Sheri CrowLyle Joyce
May 26, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Claudia HeilmannFriedhelm Beyersdorf
Sep 22, 2009·The Annals of Thoracic Surgery·Elizabeth A GenoveseRobert L Kormos
Mar 31, 2010·Thrombosis and Haemostasis·Claudia HeilmannBarbara Zieger
Nov 5, 2010·Blood·Richard D StarkeAnna M Randi
Apr 26, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Claudia HeilmannBarbara Zieger
Sep 29, 2011·Journal of Thrombosis and Haemostasis : JTH·S F DE MeyerK Vanhoorelbeke
Oct 4, 2011·Intensive Care Medicine·Claudia HeilmannBarbara Zieger
Apr 12, 2012·Blood·Yan-Feng ZhouTimothy A Springer
May 1, 2012·The Annals of Thoracic Surgery·Ashim AggarwalGeetha Bhat
Feb 8, 2013·The New England Journal of Medicine·Joseph Loscalzo
Feb 8, 2013·The New England Journal of Medicine·Ragavendra R Baliga
Feb 12, 2013·Seminars in Thrombosis and Hemostasis·Augusto B FedericiAndreas Tiede
Sep 3, 2013·Journal of the American College of Cardiology·Matthew C BunteMaria M Mountis
Oct 22, 2013·The Journal of Thoracic and Cardiovascular Surgery·Carlo R BartoliStanley E D'Souza
May 17, 2014·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Ranjan RayDipanjan Banerjee
Jun 6, 2014·Thrombosis and Haemostasis·M Franchini, P M Mannucci
Jun 15, 2014·Blood·Timothy A Springer
Jul 6, 2014·The Canadian Journal of Cardiology·Siu-Hin WanDong Chen
Jul 18, 2014·Thrombosis and Haemostasis·Antoine RauchPeter J Lenting
Sep 19, 2014·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Renzo Y Loyaga-RendonSalpy V Pamboukian
Sep 25, 2014·Journal of Thrombosis and Haemostasis : JTH·J L BlackshearD Chen
Dec 30, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Maral BaghaiBarbara Zieger
Aug 1, 2015·Nature Communications·Ying ZhengJosé A López

❮ Previous
Next ❯

Citations

Oct 2, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Yana Roka-MoiiaMarvin J Slepian
Feb 12, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Shigang WangZhongjun J Wu
Nov 3, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Yana Roka-MoiiaMarvin J Slepian
Aug 18, 2021·Annals of Biomedical Engineering·Mansur ZhussupbekovJames F Antaki
Aug 16, 2021·Hematology/oncology Clinics of North America·Arielle L Langer, Nathan T Connell
Nov 18, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Li Ying Koh, Nian Chih Hwang

❮ Previous
Next ❯

Methods Mentioned

BETA
Destination
Assist
flow cytometry

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Artificial Heart & Ventricular Assist Devices

Total artificial hearts (TAH) and ventricular assist devices (VADs) provide cardiac support for patients with end-stage heart disease and have significantly improved the survival of these patients. Discover the latest research on Artificial Heart and Ventricular Assist Devices here.

Related Papers

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Claudia HeilmannBarbara Zieger
The Journal of Thoracic and Cardiovascular Surgery
Karine NubretAlexandre Ouattara
© 2022 Meta ULC. All rights reserved