Acquired vulvar lymphangioma circumscriptum: a comparison of 12 cases with Crohn's associated lesions or radiation therapy induced tumors

Journal of Cutaneous Pathology
John A PapalasM Angelica Selim

Abstract

Lymphangioma circumscriptum (LC) is a benign lesion of lymphatic origin. Vulvar involvement occurs in various clinical settings. We present 12 cases, and compare lesions in patients with Crohn's disease and those associated with pelvic radiation. The average age at presentation was 49 years. Thirty-three percent of the patients had Crohn's disease, 58% had radiation therapy and 9% had no significant medical history. Sixty-seven percent of the patients had multifocal lesions in anatomically distinct regions. Patients presented on average 16 years after onset of predisposing factors. Presenting complaints were pruritus, wetness and vulvar edema. Lesions were clinically heterogeneous, often found on the labia majora. Lesions consisted of dilated lymphatic channels at the junction of the reticular and papillary dermis. The cells lining these spaces lacked cytologic atypicality or mitotic activity. All lesions so examined were immunoreactive for D240. Patients were most often treated with surgical excision followed by laser ablation. Four of twelve patients, all with radiation-associated lesions, experienced disease progression necessitating additional surgery. Patients with LC secondary to radiation, when compared to those with Cro...Continue Reading

References

May 1, 1976·The British Journal of Dermatology·I W Whimster
Nov 1, 1992·Journal of the American Academy of Dermatology·S L WerlinH Oechler
Apr 1, 1992·The British Journal of Dermatology·R B MallettP S Mortimer
Oct 1, 1989·Genitourinary Medicine·S E Handfield-JonesS Norman
Apr 1, 1988·The Journal of Dermatologic Surgery and Oncology·Y D Eliezri, J A Sklar
Jun 1, 1971·Chest·R M TakamotoG Troxler
Nov 1, 1970·The British Journal of Dermatology·R D PeacheyI W Whimster
Sep 1, 1980·Cancer·F Leborgne, L M Falconi
Jan 1, 1982·Urologic Radiology·P De MaeyerA De Pauw
Jan 1, 1980·Digestion·R V HeatleyE W Owen
Aug 1, 1995·Acta Obstetricia Et Gynecologica Scandinavica·E GerdinP Johnson
Aug 1, 1993·The British Journal of Dermatology·S E MoonY S Lee
Sep 1, 1993·The British Journal of Dermatology·C A Harwood, P S Mortimer
May 1, 1996·Clinical and Experimental Dermatology·D A Buckley, L Barnes
Feb 14, 1998·Plastic and Reconstructive Surgery·D D AhmedH W Randle
Nov 12, 1998·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·M ChataniT Inoue
Feb 5, 1999·Southern Medical Journal·A V CelisF W Gourdin
Jan 5, 2002·The Journal of Obstetrics and Gynaecology Research·S P SahS Rani
Jul 20, 2002·International Journal of Radiation Oncology, Biology, Physics·Ji-Hong HongSwei Hsueh
Mar 7, 2003·Magnetic Resonance Imaging·E G SolomouI Dimopoulos
May 10, 2003·Obstetrics and Gynecology·Anne-Thérèse VlastosMichele Follen
Mar 30, 2004·Gynecologic Oncology·Crystal A Moore-Maxwell, Stanley J Robboy
Jun 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Alfred GuirguisJoseph Kelley
Jul 7, 2007·International Journal of Dermatology·Paolo SbanoMichele Fimiani
Aug 19, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·F YildizA Ayhan
Nov 28, 2007·Virchows Archiv : an International Journal of Pathology·F PedicaP Baccarini
Dec 15, 2007·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·S MakhijaR Panaccione
Apr 17, 2008·Archives of Gynecology and Obstetrics·Fatemeh GhaemmaghamiAzamsadat Mousavi
Jul 18, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·R da Cunha Filho, H L de Almeida
Sep 23, 2008·Skeletal Radiology·Wim VerelstArthur De Schepper
Nov 22, 2008·Methods in Enzymology·Cornelia Halin, Michael Detmar
Jan 17, 2009·CA: a Cancer Journal for Clinicians·Brian D LawendaPeter A S Johnstone
May 8, 2009·Digestive Diseases and Sciences·Susan LeuAlan L Buchman

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Citations

Jan 26, 2013·The American Journal of Dermatopathology·John A PapalasMaria A Selim
Jan 8, 2014·Case Reports in Dermatological Medicine·Derya UçmakElif Ağaçayak
Jun 7, 2014·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Jochen HoffmannWolfgang Hartschuh
Mar 12, 2017·Actas dermo-sifiliográficas·L Padilla-EspañaC Abitei
Aug 26, 2014·The American Journal of Dermatopathology·Mai P HoangMaria A Selim
Nov 27, 2010·Journal of Cutaneous Pathology·John A Papalas, Maria A Selim
Feb 28, 2018·The Journal of Obstetrics and Gynaecology Research·Setareh AkhavanFatemeh Nili
May 20, 2021·The American Journal of Dermatopathology·Melody EsmaeiliAdam I Rubin

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