Acquisition and Loss of Secondary Metabolites Shaped the Evolutionary Path of Three Emerging Phytopathogens of Wheat

Genome Biology and Evolution
Elisha ThynnePeter S Solomon

Abstract

White grain disorder is a recently emerged wheat disease in Australia, caused by Eutiarosporella darliae, E. pseudodarliae, and E. tritici-australis. The disease cycle of these pathogens and the molecular basis of their interaction with wheat are poorly understood. To address this knowledge gap, we undertook a comparative genomics analysis focused on the secondary metabolite gene repertoire among these three species. This analysis revealed a diverse array of secondary metabolite gene clusters in these pathogens, including modular polyketide synthase genes. These genes have only been previously associated with bacteria and this is the first report of such genes in fungi. Subsequent phylogenetic analyses provided strong evidence that the modular PKS genes were horizontally acquired from a bacterial or a protist species. We also uncovered a secondary metabolite gene cluster with three polyketide/nonribosomal peptide synthase genes (Hybrid-1, -2, and -3) in E. darliae and E. pseudodarliae. In contrast, only remnant and partial genes homologous to this cluster were identified in E. tritici-australis, suggesting loss of this cluster. Homologues of Hybrid-2 in other fungi have been proposed to facilitate disease in woody plants, sugge...Continue Reading

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Citations

May 28, 2019·The New Phytologist·Lamprinos FrantzeskakisRalph Panstruga
May 19, 2020·Molecular Biology and Evolution·Emile Gluck-ThalerJason C Slot
Aug 30, 2019·Current Opinion in Genetics & Development·Jason C Slot, Emile Gluck-Thaler
Nov 17, 2020·Frontiers in Plant Science·Vijaya R ChitnisR Uma Shaanker

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Datasets Mentioned

BETA
GFXH01000000
EDA00091
KLU91681.1
EDA07266
BAJ14522.1

Methods Mentioned

BETA
environmental stress
PCR

Software Mentioned

tBLASTx
CAZyme
orthoMCL
BLASTn
Interproscan
CEGMA
MAKER
RaxML
MUSCLE
dbCAN

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