PMID: 3214541Dec 1, 1988Paper

Acquisition and reversal of taste/tactile discrimination after forebrain noradrenaline depletion

Behavioral Neuroscience
T U JarbeT Archer

Abstract

Two experiments were performed to assess the role of noradrenaline (NA) on the acquisition of an aversively motivated discrimination task and its reversal. A conditioned taste aversion procedure was used. The NA depletions were achieved through two different pharmacological means: systemic N-2-chloroethyl-N-ethyl-2-bromo-benzylamine (DSP4) and destruction of the dorsal noradrenergic bundle (DNAB) with 6-hydroxydopamine. Both procedures caused marked reductions of NA in the frontal cortex and hippocampus. In neither of the studies (Experiment 1, DSP4, and in Experiment 2, DNAB) were there any significant changes between controls and NA-depleted rats in either the rate of acquisition of the original discrimination (Phase 1) or the subsequent reversal (Phase 2). This occurred irrespective of which of the two stimuli (a taste cue, i.e., saccharin presented in bottles with nozzles that do not have ball bearings, "silent bottles," or a tongue-tactile cue, i.e., water in bottles with nozzles that had ball bearings "noisy bottles") initially was used as the conditioned stimulus (CS1, i.e., the stimulus first followed by contingent administration of lithium chloride, and later, in Phase 2, followed by saline injections). Thus NA does no...Continue Reading

Citations

Oct 1, 1989·Physiology & Behavior·J D SteketeeA C Swann
Jun 18, 1990·Behavioural Brain Research·V Devauges, S J Sara
Oct 30, 2001·Behavioural Brain Research·H WelzlH P Lipp

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