Acquisition of a novel behavior induces higher levels of Arc mRNA than does overtrained performance

Neuroscience
M P Kelly, S A Deadwyler

Abstract

Arc (also termed activity-regulated cytoskeleton-associated protein or Arg3.1), is an effector immediate early gene whose upregulation has been demonstrated during events of synaptic plasticity. In the present study, the possibility that Arc would be specifically upregulated in rats during the acquisition of a quickly learned behavioral task but not in overtrained animals was investigated. Three groups of rats, pseudotrained, newly trained and overtrained, were examined with respect to Arc expression following training on a simple operant lever-pressing task. Newly trained animals were killed 30 min following the session in which they demonstrated acquisition of the task, and overtrained animals were trained on the same task for 13-14 days and then killed. Relative to base level measures taken 6 h following the session, all three groups demonstrated significant levels of induction of Arc mRNA; however, newly trained animals exhibited heightened induction of Arc mRNA relative to both pseudotrained and overtrained animals. The increased levels of Arc mRNA in newly trained animals were located in the CA1 and CA3 fields of hippocampus, the subiculum, and the anterior cingulate, piriform, infra/prelimbic, perirhinal and entorhinal c...Continue Reading

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Citations

May 19, 2011·Psychopharmacology·Lucia CaffinoFabio Fumagalli
Apr 16, 2004·Behavioural Brain Research·Yolanda D BlackKathleen M Kantak
May 8, 2013·Behavioural Brain Research·Magdalena M SauvageZachery Beer
Jul 16, 2002·Brain Research. Molecular Brain Research·Willard M FreemanKent E Vrana
Mar 29, 2003·Learning & Memory·Monique Montag-Sallaz, Dirk Montag
Apr 12, 2011·Reviews in the Neurosciences·Daniel N Barry, Sean Commins
Feb 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sean A PintchovskiSteven Finkbeiner
Jan 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·John F GuzowskiCarol A Barnes
Sep 25, 2012·Neuroscience·D T StephensonF S Menniti
Oct 4, 2011·Trends in Neurosciences·Erica Korb, Steven Finkbeiner
Aug 19, 2015·Neurobiology of Aging·Inês Tomás PereiraPeter R Rapp
Apr 23, 2005·The European Journal of Neuroscience·Craig A SchiltzCharles F Landry
Jul 7, 2007·The European Journal of Neuroscience·D P DaberkowK A Keefe
Feb 13, 2010·Journal of Neurochemistry·Maximiliano RapanelliBonifacio Silvano Zanutto
Dec 26, 2013·Neurobiology of Aging·Xiaofang ChengJiaxiang Xiong

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