Acquisition of antibodies to variant antigens on the surface of Plasmodium falciparum-infected erythrocytes during pregnancy

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Nadine FievetPhilippe Deloron

Abstract

Pregnancy-associated malaria is characterized by Plasmodium falciparum adherence to chondroitin sulfate A (CSA) in placenta, through a particular variant surface antigen (VSA). VSA(CSA)-specific IgG are involved in protection against placental malaria. In order to assess the relationship between VSA(CSA)-specific antibody responses and parity as well as protection against placental malaria, the occurrence of P. falciparum infection was assessed in 306 pregnant women from a low malaria transmission area of Senegal. Anti-VSA(CSA) antibodies against three placental parasite isolates were measured by flow cytometry, at enrollment and delivery. Placental infection prevalence rates were highest in primigravidae, but no clear decreasing trend was observed from the second pregnancy onwards. Anti-VSA(CSA) antibody prevalence rates increased with parity. Both anti-VSA(CSA) antibody prevalence rates and levels increased during pregnancy only in women infected with P. falciparum. Although a single or a very limited number of P. falciparum infections were able to induce an anti-VSA(CSA) antibody response, the level or the quality of this response did not appear to confer protection against placental malaria infection.

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Citations

Mar 2, 2013·The Journal of Infectious Diseases·Alfredo MayorChetan E Chitnis
Nov 3, 2010·Infection and Immunity·Elisa Serra-CasasAlfredo Mayor
Jul 5, 2012·PloS One·Yeung Lo TutterrowDiane Wallace Taylor
Aug 13, 2013·PloS One·Eduard Rovira-VallbonaAlfredo Mayor
Oct 16, 2015·Vaccine·Michal Fried, Patrick E Duffy
Jan 7, 2014·Trends in Parasitology·Ricardo AtaídeStephen J Rogerson
Feb 19, 2017·Cold Spring Harbor Perspectives in Medicine·Michal Fried, Patrick E Duffy
Sep 17, 2011·Expert Review of Vaccines·Clara MenéndezGraham V Brown
Jan 5, 2017·Malaria Journal·Alexandra GueneucGwladys I Bertin

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