PMID: 2113718Apr 1, 1990Paper

Acquisition of beta-lactamase and TetM-containing conjugative plasmids by phenotypically different strains of Neisseria gonorrhoeae

Sexually Transmitted Diseases
S K SarafianJ S Knapp

Abstract

beta-lactamase plasmids confer high-level penicillin resistance on strains of Neisseria gonorrhoeae and may be mobilized between strains by conjugative plasmids. The authors examined 32 isolates belonging to 23 auxotype/serovar (A/S) classes to determine the frequency with which they acquired the 4.4-, 3.2-, and 3.05-megadalton (Mdal) beta-lactamase plasmids, respectively. The 3.05-Mdal beta-lactamase plasmid was not acquired by any isolate. Each of 22 isolates possessing only the 2.6-Mdal plasmid or both the 2.6- and 24.5-Mdal plasmids acquired the 4.4- and 3.2-Mdal plasmids at similar frequencies, and 12 (55%) acquired the 4.4- or 3.2-Mdal plasmids at a frequency of greater than or equal to 10(-3) per input recipient; all transconjugants acquired the 24.5-Mdal conjugative plasmid. Among ten isolates that lacked the 2.6-Mdal plasmid (plasmidless), seven isolates that included five PAU/IB-2, -16 isolates acquired neither the 4.4- nor 3.2-Mdal plasmid; three non-PAU isolates acquired both the 4.4- and 3.2-Mdal plasmids (10(-2)-10(-5) per input recipient). All plasmidless isolates acquired the 25.2-Mdal TetM containing plasmid with frequencies ranging from 10(-1) to 10(-8) per input recipient. These data suggest that gonococcal s...Continue Reading

Citations

Mar 6, 2004·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Valerie GrecoJo-Anne R Dillon
Aug 1, 1991·Genitourinary Medicine·C A Ison, C S Easmon
Dec 26, 2018·Infectious Diseases in Obstetrics and Gynecology·Safae KarimBahia Bennani
May 29, 1999·Antimicrobial Agents and Chemotherapy·M C RobertsK K Holmes

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