PMID: 6987329Mar 1, 1980Paper

Acquisition of cell surface IgD after in vitro culture of neoplastic B cells from the murine tumor BCL1

The Journal of Experimental Medicine
P C IsaksonE S Vitetta


Murine BCL1 tumor cells bear large amounts of surface IgM and trace amounts of surface IgD. In the present studies we have shown that cultivation of these cells, in the absence of lipopolysaccharide, results in the acquisition of IgD by virtually all the cells. These results suggest that BCL1 cells can differentiate in vitro into more mature B cells and offer an attractive model for analyzing the factors controlling appearance of IgD on a monoclonal cell line.


Jan 1, 1977·Immunological Reviews·E S Vitetta, J W Uhr
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R Levy, J Dilley
Apr 13, 1978·Nature·S Slavin, S Strober
Dec 1, 1978·The Journal of Experimental Medicine·S M FuS R Harris


Jan 1, 1983·Springer Seminars in Immunopathology·G T Stevenson, F K Stevenson
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P C IsaksonE S Vitetta
Jan 1, 1980·Immunological Reviews·E S VitettaJ W Uhr

Related Concepts

Cell Differentiation Process
Immunofluorescence Assay
Neoplasms, Experimental
Receptors, Antigen, B-Cell

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