PMID: 9537686Apr 16, 1998Paper

Acquisition of nicotine self-administration in rats: the effects of dose, feeding schedule, and drug contingency

Psychopharmacology
Eric C DonnyAlan F Sved

Abstract

The studies presented here were designed to further clarify the nature of nicotine self-administration (SA) based on a limited access model in which rats are food restricted, receive operant training using food reinforcement, and are then tested in daily 1-h drug sessions. We examined the effects of dose, feeding schedule, and contingency of drug delivery on acquisition of nicotine SA. Two doses of nicotine bitartrate, 0.03 and 0.06 mg/kg per infusion (free base), supported the transition from food-reinforced to drug-reinforced responding, although the pattern of behavior differed between these doses. In contrast, 0.01 mg/kg per infusion failed to maintain nicotine SA. In a second study, animals were divided into three groups according to feeding schedule. Rats that were both weight restricted and food deprived showed the highest level of SA behavior, although neither food deprivation nor weight restriction was necessary to establish SA. In the third experiment, rats that were switched from food to nicotine as the response-dependent reinforcer maintained higher response rates throughout a 9-day period than animals switched to response-independent (i.e., yoked) nicotine which showed minimal responding after day 1. Furthermore, t...Continue Reading

Citations

Mar 15, 2005·Psychopharmacology·Bernard Le Foll, Steven R Goldberg
Aug 10, 2006·Psychopharmacology·Shannon G MattaJeffrey M Zirger
Jan 20, 2007·Psychopharmacology·Reuven DarHanan Frenk
Oct 9, 2007·Psychopharmacology·Mahin ShahbaziKyle J Frantz
Jun 10, 2008·Psychopharmacology·Neil E RowlandWilliam R Kem
Feb 19, 2009·Psychopharmacology·Kenneth J ThielJanet L Neisewander
Jul 14, 2011·Psychopharmacology·Amanda L SharpeMichael J Beckstead
Nov 13, 2012·Psychopharmacology·Amy M GancarzJerry B Richards
Mar 23, 2013·Psychopharmacology·Katharine A BrennanPenelope Truman
Jan 24, 2004·Bioorganic & Medicinal Chemistry·M Rocío A CarreraKim D Janda
Jun 25, 2013·Neuropharmacology·Clarissa C ParkerAbraham A Palmer
Dec 4, 2003·Pharmacology, Biochemistry, and Behavior·M Dadmarz, W H Vogel
Jun 7, 2005·Pharmacology, Biochemistry, and Behavior·Caroline CohenGuy Griebel
Jun 1, 2005·Trends in Pharmacological Sciences·Bernard Le Foll, Steven R Goldberg
Feb 14, 2002·Biochemical Pharmacology·Linda P Dwoskin, Peter A Crooks
Aug 26, 2000·European Journal of Pharmacology·E C DonnyA F Sved
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Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·K Pietilä, L Ahtee
Feb 14, 2002·Pharmacology, Biochemistry, and Behavior·A R CaggiulaA F Sved
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Nov 9, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthew I PalmatierAlan F Sved
Sep 6, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Eric C DonnyAlan F Sved
Jun 7, 2007·Behavioural Pharmacology·Ami Cohen, Aaron Ettenberg
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