PMID: 11915493Mar 28, 2002Paper

Acquisition of secondary resistance after failure of a first treatment of Helicobacter pylori infection in children

Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
N KalachJ Raymond

Abstract

To assess the frequency of acquisition of secondary Helicobacter pylori resistant-strains after a first course of antimicrobial treatment. A retrospective study was performed during the 1994-2000 period, in 15 girls and eight boys, mean age 10.9 +/- 4.8 years (1.4-17 years), with Helicobacter pylori gastritis (culture and antimicrobial susceptibility) presenting a failure of first course treatment, with during one week a proton pump inhibitor and amoxicillin together with either clarithromycin (n = 14) or metronidazole (n = 9). Two endoscopies were performed, the first at the time of diagnosis and the second after the failure of bacterial eradication demonstrated by a positive 13C urea breath test six weeks after the end of treatment. Antimicrobial susceptibility of all Helicobacter pylori strains was tested after each endoscopy and before starting a second course of the treatment. Comparison of antimicrobial susceptibility before and after the first course of treatment showed that Helicobacter pylori strains were all sensitive to amoxicillin, clarithromycin-resistant in eight children (34.7%) before treatment vs 12 (52.1%) after treatment, p = 0.42, ns, metronidazole-resistant in 13 (56.5%) vs 12 (52.1%), p = 0.80, ns, and bot...Continue Reading

Citations

May 7, 2005·The Pediatric Infectious Disease Journal·Ana Isabel LopesLurdes Monteiro
Mar 4, 2008·Expert Opinion on Pharmacotherapy·Tamara SabbiLuigi Dall'Oglio
Feb 14, 2013·Journal of Pediatric Gastroenterology and Nutrition·Silvio K OgataElisabete Kawakami
Aug 29, 2002·Helicobacter·Eleftheria Roma-Giannikou, Peter L Shcherbakov

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