PMID: 15249858Jul 14, 2004Paper

Acral lentiginous melanoma in situ: a study of nine cases

The American Journal of Dermatopathology
In Ho KwonKwang Hyun Cho

Abstract

An acral lentiginous melanoma (ALM) is the most common type of cutaneous melanoma in Asians. However, it is unusual to encounter a patient showing only the histologic features of an ALM in situ. Here we describe clinical and histologic features of nine cases of ALM in situ including immunohistochemical staining with anti-S100 protein and HMB-45. All the patients had a long clinical history. Clinically, the lesions were characterized by a longitudinal pigmented streak in the nail plates, black pigmentation on the proximal or lateral nail fold, and an irregular border and variegated pigmentation on the sole or thumb. Total resections of the lesions were performed in all patients. All lesions, in both biopsy and excisional specimens demonstrated more melanocytes generally located in the basal layer of the epidermis. There was no dermal invasion. No recurrence of the disease had occurred in any patient after a follow-up period of between 6 months to 12 years after surgery. These results suggest that ALM can evolve slowly over many years.

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Citations

Feb 4, 2006·The American Journal of Dermatopathology·Yasushi IshiharaKuniaki Ohara
Oct 14, 2010·The American Journal of Dermatopathology·Anne TheunisJosette André
Apr 4, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Hsiu-Hui ChiuShih-Tsung Cheng
Oct 2, 2013·Clinics in Dermatology·Josette AndréAnne Theunis
May 10, 2011·Clinics in Laboratory Medicine·Melissa Peck Piliang
Sep 1, 2009·Surgical Pathology Clinics·Melissa Peck Piliang
Apr 4, 2009·Seminars in Cutaneous Medicine and Surgery·Bertrand RichertJosette Andre
Jan 6, 2007·The Journal of Dermatology·Isil Kilinc KaraarslanFezal Ozdemir
Apr 4, 2007·Dermatologic Therapy·Luc Thomas, Stéphane Dalle
Apr 27, 2010·International Journal of Dermatology·Ricardo HsiehMirian N Sotto
Mar 14, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·F NeczyporenkoB Richert
May 28, 2016·Seminars in Diagnostic Pathology·Mark R Wick
Jun 20, 2015·Diagnostic Pathology·José Cândido Caldeira Xavier-JúniorMariângela Esther Alencar Marques
Jan 1, 2010·Cancers·Hyun Sun Park, Kwang Hyun Cho
Jun 13, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·S GoettmannI Zaraa
Jun 5, 2010·Annals of Dermatology·Jung Min BaeYoung Min Park
Oct 20, 2018·The American Journal of Dermatopathology·Oscar W Nevares-PomalesJorge L Sanchez
Jul 27, 2007·Virchows Archiv : an International Journal of Pathology·Guido Massi
Aug 14, 2019·Chinese Medical Journal·Fei Gao, Lin-Lin Xin
Feb 22, 2014·The American Journal of Dermatopathology·Jin Yong KimKwang Hyun Cho

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