Acrochordons as a presenting sign of nevoid basal cell carcinoma syndrome

Journal of the American Academy of Dermatology
E Chiritescu, M E Maloney

Abstract

Nevoid basal cell carcinoma syndrome (NBCCS) is a genodermatosis with autosomal dominant inheritance. In identified kindreds the diagnosis is relatively easy, but for the patients without family history of this syndrome a high clinical suspicion is necessary for diagnosis. Acrochordons are distinctly uncommon in childhood. Our purpose was to evaluate skin tags that develop at an early age. This is a retrospective series evaluation of 7 children who presented with pedunculated papules (acrochordon-like growths). A full history was then correlated with biopsy results in each patient. Clinically, lesions consisted of flesh-colored and pigmented pedunculated papules. Histopathologic examination of these papules showed basal cell carcinomas in each biopsy specimen. We consider that "skin tag"-like basal cell carcinomas in childhood may represent a marker for NBCCS. Early diagnosis of this syndrome and early sun protection of the affected children could help decrease the number of lifetime tumors. Biopsy should be performed on acrochordons in children because they may be the presenting sign of NBCCS. Because these tags may precede other stigmata of the NBCCS, recognition may facilitate early diagnosis and allow early treatment and su...Continue Reading

Citations

Aug 25, 2012·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Virginia E KimonisSherri J Bale
Dec 18, 2004·Dermatology : International Journal for Clinical and Investigative Dermatology·Onder TanIrfan Bayram
Jan 27, 2010·Indian Journal of Dermatology·Omar Soliman El SafouryDalia H Mohamed
Jan 1, 2011·Annals of Maxillofacial Surgery·Vimal KaliaGeeta Kalra
Apr 4, 2017·Clinical Nuclear Medicine·Gozde Daglioz GorurHakan Demir
Feb 2, 2008·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Briana C Gleason, Sara O Vargas
Jul 13, 2006·American Journal of Medical Genetics. Part a·J Lawrence MerrittDusica Babovic-Vuksanovic
Nov 9, 2007·International Journal of Dermatology·Abbas RasiNasim Shahbazi
Apr 22, 2008·Journal of Cutaneous Pathology·Jameel Ahmad Brown, Michael B Morgan
Sep 22, 2012·Journal of Cutaneous Pathology·Colt M McClainSara M Kantrow
Aug 9, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Sanjay SinghSavita Yadav
Dec 23, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·E SenelB Berçik İnal
Sep 12, 2015·International Journal of Dermatology·Livia Cristina de Melo PinoOmar Lupi
Mar 25, 2005·International Urology and Nephrology·Levent EmirDemokan Erol
Oct 12, 2020·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Gabriella FredmanMette Mogensen
May 23, 2021·The Journal of Dermatology·Francesca BesagniIria Neri
Feb 24, 2009·Journal of the American Academy of Dermatology·Marta Feito-RodríguezAngel Pizarro

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Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

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