Acrogranin, an acrosomal cysteine-rich glycoprotein, is the precursor of the growth-modulating peptides, granulins, and epithelins, and is expressed in somatic as well as male germ cells

Molecular Reproduction and Development
T BabaG L Gerton

Abstract

Spermatogenesis is a unique system of differentiation involving cellular remodeling and the biogenesis of sperm-specific organelles. To study the biogenesis of one such organelle, the acrosome, we have been examining the gene expression, biosynthesis, and targeting of specific acrosomal proteins during mammalian spermatogenesis. An acrosomal marker that we recently purified and began characterizing is acrogranin, a 67,000-molecular-weight glycoprotein originally isolated from guinea pig testes. This glycoprotein is detected in pachytene spermatocytes and is found later in the acrosomes of developing spermatids and sperm. Immunoblotting of several tissues and immunofluorescent localization in frozen sections of guinea pig testes suggested that acrogranin was a germ cell-specific glycoprotein that was expressed meiotically and post-meiotically. However, Northern blot analysis demonstrated that the mRNA for acrogranin was ubiquitously expressed in all guinea pig and mouse tissues examined. Furthermore, the primary structures of guinea pig and mouse acrogranins, deduced from the cDNA sequences, reveal that this glycoprotein is a cysteine-rich molecule with a motif that is tandemly repeated seven times, very similar to that of the h...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·V BhandariA Bateman
Nov 30, 1990·Biochemical and Biophysical Research Communications·S KashiwabaraT Baba
Jun 1, 1991·Journal of Biochemistry·K WatanabeY Arai
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M ShoyabG D Plowman
Dec 31, 1990·Biochemical and Biophysical Research Communications·A BatemanS Solomon
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D L Kilpatrick, C F Millette
Jan 1, 1988·Developmental Biology·C E Arboleda, G L Gerton
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Sep 1, 1965·The Journal of Cell Biology·A K Christensen

❮ Previous
Next ❯

Citations

Sep 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M BucanG L Gerton
Dec 1, 2009·Acta Neuropathologica·Swati B NaphadeJeff Kuret
Jun 22, 2011·Journal of Molecular Neuroscience : MN·Huishi TohAndrew Bateman
Aug 25, 2011·Journal of Molecular Neuroscience : MN·Samir Kumar-Singh
Dec 15, 2012·Molecular Neurobiology·Gernot KleinbergerChristine Van Broeckhoven
Dec 26, 2001·Archives of Medical Research·L Díaz-Cueto, G L Gerton
Mar 4, 2000·Peptides·S M AliD P Brooks
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T G WolfsbergJ M White
Feb 25, 2009·Carcinogenesis·Francesca LovatAndrea Morrione
May 20, 2005·Biology of Reproduction·Junwen QinKazuhiko Imakawa
Feb 4, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jian Q FengChuan-Ju Liu
Jul 30, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fangfang YinAihao Ding
Feb 18, 2003·Molecular and Cellular Biology·Mainul HoqueTsafi Pe'ery
Nov 10, 2005·BMC Genomics·Benoît CadieuxHugh P J Bennett
Dec 3, 2010·The Journal of Reproduction and Development·Johannes StubertVolker Briese
Jun 25, 2009·The Journal of Reproduction and Development·Shuichi ChibaMasugi Nishihara
Sep 2, 2009·The Journal of Reproduction and Development·Masatoshi SuzukiMasugi Nishihara
Dec 15, 2010·International Journal of Biological Sciences·Zhengguo CaoJian Q Feng
Feb 16, 2002·Biochemical and Biophysical Research Communications·Victoriano BaladrónJorge Laborda
Oct 20, 2011·Pharmacology & Therapeutics·Chuan-ju Liu, Xavier Bosch
Dec 24, 2015·Diabetology & Metabolic Syndrome·Bruna Bellincanta Nicoletto, Luis Henrique Canani
Dec 10, 2008·Developmental and Comparative Immunology·Patrick C HaningtonMiodrag Belosevic
Mar 11, 2008·Trends in Genetics : TIG·Marc Cruts, Christine Van Broeckhoven
Oct 2, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Andrew Bateman, Hugh P J Bennett
Mar 25, 2008·Protein Science : a Publication of the Protein Society·Dmitri TolkatchevFeng Ni
Aug 26, 2010·The Journal of Comparative Neurology·Terri L PetkauB R Leavitt
Nov 13, 2004·Biochimica Et Biophysica Acta·Kazuhiro NaraTetsushi Naraoka
Oct 3, 2006·General and Comparative Endocrinology·Mark Hung-Chih ChenJen-Leih Wu
Aug 19, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ali Ozgur ErsoyNafiye Yilmaz
Feb 18, 2012·Brain Research·Jennifer GassLeonard Petrucelli
Oct 25, 2000·Mechanisms of Development·K Wertz, B G Herrmann
Mar 2, 2010·Journal of Proteomics·Kriangsak SongsriroteJane Thomas-Oates
Mar 31, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Wan-Sheng LiuMichael O'Connor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.