Acrolein Contributes to the Neuropathic Pain and Neuron Damage after Ischemic-Reperfusion Spinal Cord Injury

Neuroscience
Yazhou LinRiyi Shi

Abstract

Besides physical insult, spinal cord injury (SCI) can also result from transient ischemia, such as ischemia-reperfusion SCI (I/R SCI) as a postoperative complication. Increasing evidence has suggested that oxidative stress and related reactive aldehyde species are key contributors to cellular injury after SCI. Previous work in spinal cord contusion injury has demonstrated that acrolein, both a key product and an instigator of oxidative stress, contributes to post-traumatic hyperalgesia. It has been shown that acrolein is involved in post-SCI hyperalgesia through elevated activation, upregulating, and sensitizing transient receptor potential ankyrin 1 (TRPA1) in sensory neurons in dorsal root ganglia. In the current study, we have provided evidence that acrolein likely plays a similar role in hypersensitivity following I/R SCI. Specifically, we have documented a post-I/R SCI hypersensitivity, with parallel elevation of acrolein locally (spinal cord tissue) and systemically (urine), which was also accompanied by augmented TRPA1 mRNA in DRGs. Interestingly, known aldehyde scavenger phenelzine can significantly alleviate post-I/R SCI hypersensitivity, reduce acrolein, suppress TPRA1 upregulation, and improve motor neuron survival. ...Continue Reading

Citations

Jun 15, 2019·International Journal of Molecular Sciences·Simona GiorgiSara González-Rodríguez
Feb 6, 2021·Brain Research·Mushfiquddin KhanInderjit Singh
Dec 4, 2020·Tissue Engineering. Part B, Reviews·Jiao Jiao LiBin Zhao
Apr 12, 2021·Cellular and Molecular Neurobiology·Dmitriy MatveychukGlen B Baker
Apr 24, 2021·The Journal of Spinal Cord Medicine·Brianna KishYunjie Tong
Jan 13, 2021·The Annals of Thoracic Surgery·Zara KhachatryanChristian D Etz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.