Acromegaly: a cross-sectional analysis of the oral and maxillofacial pathologies

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
B L HerrmannK Mann

Abstract

It is well established that clinical features of acromegaly concern the teeth and the jaw, but less is known about the degree of oral and maxillofacial pathologies. 28 acromegalics (13 females, 15 males) with a mean age 49±11 (mean±SD) years (range 31-70) were included in the study. 32% had active disease, 68% were well-controlled under the somatostatin analogue octreotide, the dopamine agonist cabergoline, and the GH receptor antagonist pegvisomant, or were cured after pituitary surgery and/or radiation. All subjects undergone intensive and complex examinations of a plaster model and facial arch with articulator, an intra-oral bracket-pen registration, analysis of a digital picture, panoramic and lateral radiographs with cephalometry in comparison with a reference group (n=201). 42% had a diastema mediale (0.9±1.1 mm). Overbite and overjet (vertical overbite) correlated with the disease duration (r²=0.2237; p=0.011 respectively r²=0.3364; p=0.015). 96% had an asymmetric movement of the mandible. 57% had a prognathism. The protrusion of the mandible correlated significantly with the disease duration (r²=0.1784; p=0.028). The degree of the mandibular prognathism (SNB-angle) was higher in the acromegalic group (84°±7° vs. 81°±3°,...Continue Reading

Citations

Apr 8, 2015·American Journal of Medical Genetics. Part a·Despoina ManousakiCheri Deal
Mar 10, 2018·Endocrine·Ilonka Kreitschmann-AndermahrSonja Siegel
Jun 19, 2012·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Anthony J FischettiMark E Peterson
Nov 6, 2020·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·Mehmet Berk KaffafOlcay Şakar
Jun 3, 2021·The Journal of Craniofacial Surgery·Caroline DissauxLaetitia Ruffenach

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