PMID: 6162509Jan 26, 1981Paper

'Acrylamide-induced' neuropathy and impairment of axonal transport of proteins. I. Multifocal retention of fast transported proteins at the periphery of axons as revealed by light microscope radioautography

Brain Research
F SouyriB Droz

Abstract

The axonal transport of proteins was studied in ciliary ganglia of control and acrylamide-treated chickens. After an intracerebral injection of [3H]lysine, the distribution of axonally transported proteins was analyzed in the preterminal segments of preganglionic axons and in their caliciform nerve endings by means of quantitative light microscope radioautography. By 7 days after the injection of [3H]lysine, the concentration of labeled proteins in the preganglionic axons was either similar or slightly increased in acrylamide-treated chickens as compared to controls. In contrast, by 3 h, whereas the axons of controls were poorly radioactive, 20-30% of the axons in acrylamide-treated chickens displayed focal and intense labeling at their periphery; simultaneously, in acrylamide treated chickens, 20-30% of the nerve endings contained a decreased amount of radioactive proteins. It is concluded that acrylamide induces multifocal retention of fast axonally transported proteins in preterminal segments of certain axons.

References

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Citations

Mar 1, 1992·Journal of Neuroscience Research·G J HarryT W Bouldin
Sep 1, 1985·Archives of Toxicology·J Sakamoto, K Hashimoto
Sep 13, 2002·Neurotoxicology·Dale W SicklesMarvin A Friedman
Aug 1, 1993·Journal of Toxicology and Environmental Health·S PadillaA C Breuer
Jul 20, 2012·Continuum : Lifelong Learning in Neurology·Brett Morrison, Vinay Chaudhry
Mar 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·A V TerryM A Prendergast
Oct 1, 1985·Journal of Cellular Physiology·J V OlanderJ Feder
Mar 27, 1989·Brain Research·M I SabriP S Spencer

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