PMID: 6162510Jan 26, 1981Paper

'Acrylamide-induced' neuropathy and impairment of axonal transport of proteins. II. Abnormal accumulations of smooth endoplasmic reticulum as sites of focal retention of fast transported proteins. Electron microscope radioautographic study

Brain Research
M ChretienB Droz

Abstract

The distribution of fast axonally transported proteins was studied by electron microscope radioautography in ciliary ganglia of chickens treated or not treated with acrylamide. At 3 h after the intracerebral injection of [3H]lysine, the preganglionic axons of the untreated chickens displayed few silver grains, mainly associated with smooth endoplasmic reticulum (SER) profiles. In most axons of acrylamide-treated chickens, a similar pattern was observed, except in axons which exhibited focal and intense labeling underneath the axolemma: clusters of silver grains indeed overlayed peripheral accumulations of tubulovesicular profiles of SER, dense core vesicles and mitochondria. After impregnation with heavy metals, electron microscope observation of 1 micrometer thick sections showed a locally disorganized SER forming a complex network of tubules intermingled with vesicles and mitochondria. Such a local disorganization of the peripheral SER in the distal part of the axons, could be responsible for the focal stasis of fast transported proteins; it seems to be one of the earliest changes detectable in axons damaged by acrylamide treatment.

References

Mar 1, 1977·Journal of Neuropathology and Experimental Neurology·J W GriffinD B Drachman
Jul 1, 1977·Journal of Neurobiology·J W GriffinD B Drachman
Sep 1, 1979·Journal of Neuropathology and Experimental Neurology·Z Sahenk, J R Mendell
Sep 1, 1977·Journal of Neuropathology and Experimental Neurology·K SaidaZ Sahenk
Sep 1, 1977·Journal of the Neurological Sciences·E J Post, J G McLeod
Jul 1, 1966·British Journal of Industrial Medicine·P M Fullerton, J M Barnes
Jun 1, 1974·Brain : a Journal of Neurology·J A Morgan-HughesJ H Durston
Jan 1, 1964·Journal of Neuropathology and Experimental Neurology·P LAMPERTA PENTSCHEW

❮ Previous
Next ❯

Citations

Mar 1, 1992·Journal of Neuroscience Research·G J HarryT W Bouldin
Sep 1, 1985·Archives of Toxicology·J Sakamoto, K Hashimoto
Mar 27, 1989·Brain Research·M I SabriP S Spencer
Mar 1, 1991·Pediatric Neurology·S Kimura
Jun 9, 2004·Neurotoxicology·Richard M LoPachin
Sep 13, 2002·Neurotoxicology·Dale W SicklesMarvin A Friedman
Aug 1, 1993·Journal of Toxicology and Environmental Health·S PadillaA C Breuer
Oct 1, 1991·Reviews on Environmental Health·E A Smith, F W Oehme
Sep 16, 2006·Critical Reviews in Toxicology·A ShippC Van Landingham
May 1, 1984·Neuropathology and Applied Neurobiology·A B Sterman
Dec 1, 1985·Journal of Neurochemistry·M A Bisby
Aug 15, 1996·Microscopy Research and Technique·K P Gatzinsky
Mar 1, 1983·Journal of Neurochemistry·P Sidenius, J Jakobsen
Sep 1, 1982·Neuropathology and Applied Neurobiology·J W GriffinH E Lowndes
Mar 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·A V TerryM A Prendergast
Feb 9, 2019·Central Nervous System Agents in Medicinal Chemistry·Shinomol George KunnelFarhan Zameer
Jan 1, 1988·Annals of Neurology·J W Griffin, D F Watson
Feb 1, 1983·Muscle & Nerve·J JakobsenP Sidenius

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.