Acteoside attenuates TSLP-induced mast cell proliferation via down-regulating MDM2

International Immunopharmacology
Myoung-Schook YoouHyun-Ja Jeong

Abstract

Acteoside (verbascoside) is extensively distributed in Abeliophyllum distichum and has antimicrobial and anti-inflammatory properties. Thymic stromal lymphopoietin (TSLP) has a pivotal function in the pathogeneses of inflammatory diseases through increasing the mast cell proliferation via the activation of murine double minute 2 (MDM2). Here, we investigate whether acteoside attenuates the MDM2 expression in a TSLP-stimulated human mast cell line (HMC-1 cells). In these cells, TSLP induced the up-regulation of MDM2 and the down-regulation of p53; however, in the TSLP-stimulated HMC-1 cells, the acteoside down-regulated the MDM2 and up-regulated the p53. Increases in the phosphorylation of the single transducer and activation of transcription 6 and 5 via TSLP are decreased by acteoside. The interleukin (IL)-13 (a mast cell growth factor), IL-6, tumor necrosis factor-α, and IL-1β levels are significantly reduced by the acteoside in the TSLP-stimulated HMC-1 cells, and the acteoside significantly induces the activation of caspase-3, the cleavage of poly-ADP-ribose polymerase, and the reduction of the procaspase-3 and Bcl2. Furthermore, the mRNA expressions of the TSLP receptor and IL-7 receptor that increase due to TSLP are reduce...Continue Reading

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Citations

Dec 24, 2015·European Journal of Pharmacology·Myoung-schook YoouHyun-Ja Jeong
Oct 11, 2015·International Immunopharmacology·Sun-Young NamHyun-Ja Jeong
Nov 7, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guoyong XieMinjian Qin
Dec 2, 2017·Clinical and Experimental Pharmacology & Physiology·Na-Ra HanHyun-Ja Jeong
Oct 11, 2020·European Journal of Medicinal Chemistry·Xiu-Yu TianLi-Ping Chen

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