Acteoside protects endothelial cells against free radical-induced oxidative stress

The Journal of Pharmacy and Pharmacology
Wen Fei ChiouChieh Fu Chen

Abstract

The protective effect of acteoside against membrane lipid oxidation and free radical-mediated impairment of endothelial function was investigated. Results showed that iron-mediated oxidative modification of the cell membrane in cultured bovine pulmonary endothelial cells (PAECs) was significantly attenuated by acteoside as measured by thiobarbituric acid-reactive substances (TBARS). Fenton's reagent (H2O2/Fe2+) was used to generate hydroxyl radicals (*OH) and induce oxidative stress. Acteoside not only effectively minimized the loss of cell viability induced by hydroxyl radicals in cultured endothelial cells but also countered the free radical-induced destruction of the endothelium-dependent relaxation to acetylcholine in rat aorta. Furthermore, acteoside showed a dose-dependent scavenging effect of 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radicals and appeared to be the most efficient in comparison with the four reference compounds (alpha-tocopherol, vitamin C, probucol and resveratrol). These data suggested that acteoside protects the cell from oxidative stress and that scavenging of free radicals could be a key mechanism contributing to the cytoprotective effect of acteoside.

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Citations

May 3, 2011·Journal of Asian Natural Products Research·Jiang HeZhen-Dan He
Dec 4, 2008·The American Journal of Chinese Medicine·Viduranga Y WaisundaraBenny Kwong-Huat Tan
Dec 25, 2015·Molecular Pharmacology·Xiaoran ZhaoXiaodi Niu
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Jul 27, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Dongfang WangLi Gu
Jun 21, 2019·International Journal of Molecular Sciences·Lingling YangXueqin Ma
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Nov 25, 2020·Antioxidants·Hak-Dong LeeSanghyun Lee
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dóra KósaZoltán Ujhelyi
Apr 27, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bartosz SkalskiBeata Olas
Feb 25, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jie CuiJingcheng Dong

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