Actigraphy Detects Greater Intra-Individual Variability During Gait in Non-Manifesting LRRK2 Mutation Carriers

Journal of Parkinson's Disease
Lieneke van den HeuvelC Marras

Abstract

With recent advances in the search for disease-modifying therapies for Parkinson's disease (PD) the importance of identifying prodromal markers becomes greater. Non-manifesting LRRK2 mutation carriers (NMC) are at risk for developing PD, and provide a population in which to identify possible markers. The aim of this study was to test the hypothesis that NMC have differences in daily activity, fragmentation of sleep, arm swing asymmetry, and movement variability during walking, detectable by actigraphy, as compared to matched control subjects. Eleven NMC, fourteen PD patients (4 LRRK2-PD, 10 idiopathic PD (iPD)), and twenty-nine controls wore wristbands containing an accelerometer for seven days, and performed a daily walking task. Outcome measures included daily activity, fragmentation of activity, fragmentation of sleep, arm swing asymmetry during walking, and intra-individual variability. Compared to healthy controls, both NMC and LRRK2/iPD showed higher intra-individual variability in activity during walking compared to healthy controls. Individuals with LRRK2-PD/iPD, but not NMC, tend to have lower activity levels, more arm swing asymmetry and less increase of arm swing with transition from slow to faster walking speed comp...Continue Reading

References

Jan 18, 2008·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Ilaria CarpinellaMaurizio Ferrarin
Jun 10, 2008·Lancet Neurology·Daniel G HealyUNKNOWN International LRRK2 Consortium
Nov 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Claire L TomlinsonCarl E Clarke
Feb 1, 2011·Annals of Neurology·Anat MirelmanJeffrey M Hausdorff
Jun 7, 2011·Parkinsonism & Related Disorders·Krisztina K JohansenJan O Aasly
Mar 30, 2012·PloS One·Walter MaetzlerLorenzo Chiari
Jun 12, 2013·Physiology & Behavior·Weidong PanDingfang Cai
Mar 13, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Daniela BergGünther Deuschl
Apr 2, 2014·JAMA Neurology·David P BreenRoger A Barker
Dec 3, 2014·Gait & Posture·A PlateK Bötzel
Mar 27, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Anat MirelmanUNKNOWN LRRK2 AJ consortium
Aug 26, 2015·PloS One·Anat MirelmanJeffrey M Hausdorff
Oct 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Daniela BergGünther Deuschl
Apr 20, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Connie MarrasUNKNOWN LRRK2 Cohort Consortium

❮ Previous
Next ❯

Citations

Mar 29, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Ronald B Postuma, Daniela Berg
Jan 29, 2019·Neurophysiologie clinique = Clinical neurophysiology·Nathalie Chastan, Leslie M Decker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Parkinsonism & Related Disorders
Beatriz TijeroJuan José Zarranz
Movement Disorders : Official Journal of the Movement Disorder Society
Anat MirelmanNir Giladi
Advances in Neurobiology
Meir Kestenbaum, Roy N Alcalay
© 2022 Meta ULC. All rights reserved