DOI: 10.1101/494427Dec 17, 2018Paper

Actimetry in infant sleep research: an approach to facilitate comparability

BioRxiv : the Preprint Server for Biology
Sarah SchochSalome Kurth

Abstract

Study Objectives: Only standardized objective assessments reliably capture the large variability of sleep behavior in infancy, which is the most pronounced during the human lifespan. This is important for clinical as well as basic research. Actimetry is a cost-efficient method to objectively track infant sleep/wake behavior by assessing limb movements. Nevertheless, the standardization of actimetry-based sleep/wake measures is limited by two factors: the use of different computational approaches and the bias towards measuring only nighttime sleep - neglecting ~20 % of sleep infants obtain during daytime. Methods: We used actimetry in 50 infants for 10 continuous days at ages 3, 6 and 12 mo in a longitudinal approach. We analyzed the infant' sleep/wake behaviors applying with two commonly used algorithms: Sadeh and Oakley/Respironics. We compared minute-by-minute agreement and Kappa between the two algorithms, as well as the algorithms with sleep/wake measures from a comprehensive 24-hour, parent-reported diary. Results: Agreement between uncorrected algorithms was moderate (77 - 84%). By introducing a 6-step adjustment, we increased agreement between algorithms (96 - 97%) and with the diary. This decreased the difference betwee...Continue Reading

Related Concepts

Research
Sleep
Evaluation
Limb Movement
Protein Purification
Sleep Disorders
Analysis
Computed (Procedure)
Orientation (spatial)
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