Actin Aggregations Mark the Sites of Neurite Initiation

Neuroscience Bulletin
Shu-Xin ZhangXiang Yu

Abstract

A salient feature of neurons is their intrinsic ability to grow and extend neurites, even in the absence of external cues. Compared to the later stages of neuronal development, such as neuronal polarization and dendrite morphogenesis, the early steps of neuritogenesis remain relatively unexplored. Here we showed that redistribution of cortical actin into large aggregates preceded neuritogenesis and determined the site of neurite initiation. Enhancing actin polymerization by jasplakinolide treatment effectively blocked actin redistribution and neurite initiation, while treatment with the actin depolymerizing agents latrunculin A or cytochalasin D accelerated neurite formation. Together, these results demonstrate a critical role of actin dynamics and reorganization in neurite initiation. Further experiments showed that microtubule dynamics and protein synthesis are not required for neurite initiation, but are required for later neurite stabilization. The redistribution of actin during early neuronal development was also observed in the cerebral cortex and hippocampus in vivo.

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Citations

Oct 21, 2016·Neuroscience Bulletin·Yu-Chao ZuoHong-Yang Zhao
Nov 21, 2019·American Journal of Physiology. Cell Physiology·Francisco J UrbanoEdgar Garcia-Rill
Oct 30, 2019·Cellular and Molecular Life Sciences : CMLS·Sarah A BennisonKazuhito Toyo-Oka
Jan 10, 2018·Neurochemical Research·Yijia ShenYuanchang Xiong
Sep 4, 2021·Journal of Neurochemistry·Thanushiyan PoobalasingamPhillip R Gordon-Weeks

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