Actin Crosslinking Toxins of Gram-Negative Bacteria.

Toxins
Karla J F Satchell

Abstract

Actin crosslinking toxins produced by Gram-negative bacteria represent a small but unique class of bacterial protein toxins. For each of these toxins, a discrete actin crosslinking domain (ACD) that is a distant member of the ATP-dependent glutamine synthetase family of protein ligases is translocated to the eukaryotic cell cytosol. This domain then incorporates a glutamate-lysine crosslink between actin monomers, resulting in destruction of the actin cytoskeleton. Recent studies argue that the function of these toxins during infection is not destruction of epithelial layers, but rather may specifically target phagocytic cells to promote survival of bacteria after the onset of innate immune defenses. This review will summarize key experiments performed over the past 10 years to reveal the function of these toxins.

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Citations

Jul 18, 2001·Chemistry and Physics of Lipids·K LohnerP Garidel
Jan 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jayme S KwakKarla J F Satchell
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Apr 7, 2011·The FEBS Journal·Klaus AktoriesHans G Mannherz
Mar 12, 2015·Acta Crystallographica. Section F, Structural Biology Communications·Van Son NguyenAlain Roussel
Apr 8, 2015·Infection and Immunity·Jessica QueenKarla J F Satchell
Aug 18, 2012·The Journal of Biological Chemistry·Eric DurandChristian Cambillau
Dec 6, 2018·Toxins·Byoung Sik Kim
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Julia Monjarás Feria, Miguel A Valvano
Apr 20, 2019·International Journal of Biological Macromolecules·Priyanka DuttaSankar Maiti

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