Actin flows in cell migration: from locomotion and polarity to trajectories

Current Opinion in Cell Biology
Andrew Callan-Jones, R Voituriez

Abstract

Eukaryotic cell movement is characterized by very diverse migration modes. Recent studies show that cells can adapt to environmental cues, such as adhesion and geometric confinement, thereby readily switching their mode of migration. Among this diversity of motile behavior, actin flows have emerged as a highly conserved feature of both mesenchymal and amoeboid migration, and have also been identified as key regulators of cell polarity. This suggests that the various observed migration modes are continuous variations of elementary locomotion mechanisms, based on a very robust physical property of the actin/myosin system - its ability to sustain flows at the cell scale. This central role of actin/myosin flows is shown to affect the large scale properties of cell trajectories.

References

Jul 11, 1991·Nature·J A Theriot, T J Mitchison
May 2, 2003·Nature Reviews. Cancer·Peter Friedl, Katarina Wolf
Mar 5, 2004·Physical Review Letters·K KruseK Sekimoto
Feb 3, 2005·The European Physical Journal. E, Soft Matter·K KruseK Sekimoto
Nov 19, 2005·Science·Dennis E DischerYu-Li Wang
Feb 21, 2006·Physical Review Letters·R VoituriezJ Prost
Jul 17, 2008·Nature Reviews. Molecular Cell Biology·Guillaume Charras, Ewa Paluch
Jul 23, 2008·Physical Review Letters·A C Callan-JonesJ Prost
Dec 17, 2008·Science·Gabrielle Faure-AndréAna-Maria Lennon-Duménil
Mar 5, 2009·Physical Review Letters·R J HawkinsR Voituriez
Jun 16, 2009·Current Opinion in Cell Biology·Tim Lämmermann, Michael Sixt
Aug 27, 2009·Cellular and Molecular Life Sciences : CMLS·K PankováJan Brábek
Oct 2, 2009·Physical Review Letters·G SalbreuxJ F Joanny
Nov 17, 2009·Nature Cell Biology·Jörg RenkawitzMichael Sixt
Jun 22, 2010·Nature Physics·A ZemelS A Safran
Sep 11, 2010·Current Opinion in Cell Biology·Victoria Sanz-Moreno, Christopher J Marshall
Jan 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Renaud PoinclouxPhilippe Chavrier
Oct 25, 2011·Science·Nathan W GoehringStephan W Grill
Apr 3, 2012·Physical Review Letters·Vincent TejedorOlivier Bénichou
Apr 18, 2012·Proceedings of the National Academy of Sciences of the United States of America·Léa TrichetBenoît Ladoux
Jul 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Martin BergertEwa Paluch
Aug 9, 2012·Trends in Cell Biology·Guillaume SalbreuxEwa Paluch
Sep 15, 2012·Current Biology : CB·Paolo MaiuriManuel Théry
Nov 28, 2012·Trends in Cell Biology·Nathan W Goehring, Stephan W Grill
Jun 22, 2013·Current Opinion in Cell Biology·Ewa K Paluch, Erez Raz
Aug 6, 2013·Annual Review of Cell and Developmental Biology·Gaudenz DanuserAlex Mogilner
Aug 28, 2013·The Journal of Cell Biology·Wei-Chien HungKonstantinos Konstantopoulos
Oct 15, 2013·Immunological Reviews·Mélina L HeuzéAna-Maria Lennon-Duménil
May 21, 2014·ELife·Enas Abu Shah, Kinneret Keren
Feb 15, 2013·Physical Review Letters·C Blanch-Mercader, J Casademunt
Aug 29, 2014·Physical Review Letters·P RechoL Truskinovsky
Nov 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jian ZhangYu-Li Wang
Feb 14, 2015·Cell·Verena RuprechtCarl-Philipp Heisenberg
Mar 17, 2015·Nature Cell Biology·Martin BergertEwa K Paluch
Jun 26, 2015·Nature Communications·Mukund GuptaBenoît Ladoux
Jun 26, 2015·Nature Communications·Mélanie ChabaudAna-Maria Lennon-Duménil
Aug 4, 2015·Cytoskeleton·Roman Gorelik, Alexis Gautreau
Aug 15, 2015·Nature Communications·Mélanie ChabaudAna-Maria Lennon-Duménil

❮ Previous
Next ❯

Citations

Jun 28, 2016·Pharmacology & Therapeutics·Alan R Parrish
Apr 5, 2018·Molecular & Cellular Proteomics : MCP·Tina BeyerKarsten Boldt
Oct 5, 2019·Nature Reviews. Molecular Cell Biology·Kenneth M Yamada, Michael Sixt
Jul 14, 2017·Cellular and Molecular Life Sciences : CMLS·Anna Melkov, Uri Abdu
Jul 25, 2019·Physical Review. E·Christian Bächer, Stephan Gekle
Mar 3, 2020·Frontiers in Cell and Developmental Biology·Jing Xie, Nicolas Minc
Dec 29, 2019·Proceedings of the National Academy of Sciences of the United States of America·Luiza StankevicinsFranziska Lautenschläger
Oct 18, 2020·Communications Biology·Jip ZonderlandLorenzo Moroni
Sep 12, 2020·Cell Systems·Greg M AllenAlex Mogilner
Apr 18, 2021·Physical Review. E·Ushasi Roy, Andrew Mugler
May 16, 2021·Nature Reviews. Molecular Cell Biology·Shuvasree SenGuptaJames E Bear
May 15, 2020·Biophysical Journal·Ismael FortunaRita M C de Almeida

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Scientific American
R D Allen
The Journal of Cell Biology
Peter Friedl, Katarina Wolf
Symposia of the Society for Experimental Biology
L Wolpert, D Gingell
© 2021 Meta ULC. All rights reserved