Actin microfilaments and fibroin secretion in the silkgland cells of Bombyx mori. Effects of cytochalasin B

Experimental Cell Research
P CoubleJ C Prudhomme

Abstract

Bombyx mori posterior silkgland cells exhibit an impressive microfilament apparatus located at the cellular apex. It consists of bundles of packed, long microfilaments of 50-70 A diameter running along circumferences delimiting the lumen of the gland, perpendicularly to the flow of luminal silk. Microfilaments are closely associated with microtubules of the cytoplasmic 'radial microtubule system'. Immunolabelling with purified antihuman actin antibodies was used to demonstrate their actin-like nature. Apical microfilaments are sensitive to cytochalasin B (CB) which selectively inhibits the secretion of fibroin. Following the removal of the drug, microfilaments recover their normal morphology and secretion resumes. The possible implication of contraction of microfilaments in the process of secretion is discussed.

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Citations

May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A J WieczorekL H Block
Jun 17, 2008·Micron : the International Research and Review Journal for Microscopy·Jônatas Bussador do Amaral, Gláucia Maria Machado-Santelli
Mar 21, 2006·Proteomics·Pingbo ZhangHiroshi Fujii
Dec 29, 2005·Archives of Insect Biochemistry and Physiology·YuanXiang JinMengKui Xu

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