Actin modifications and calcium homoeostasis in neurotoxicity. The case of organotin salts

Toxicology in Vitro : an International Journal Published in Association with BIBRA
M MarinovichC L Galli

Abstract

The cytoskeleton is a major constituent of the neuronal cytoplasm; it controls cell shape and plays important roles in regulating various physiological processes. In neurons, actin filaments are involved in the growth of the neurite and the neurotransmitter release. Recent findings suggest that actin filaments play a role in modulating [Ca(2+)](i) responses to neurotoxic insults. The physiological functioning of the neural cell is critically dependent on the intracellular distribution of calcium. An increase of cytosolic free calcium can activate a number of intracellular reactions, including neurotransmitter release, protein phosphorylation, protease activity, and, eventually, cell death. Many neurotoxic agents with diverse mechanisms have been reported to affect mechanisms associated with calcium. Among these are organotin compounds: they can both raise the cytosolic and synaptosomal [Ca(2+)](i) concentrations and interfere with the [Ca(2+)](i) response evoked by different agonists. Furthermore, some of these compounds cause actin depolymerization. The interference of triethyltin (TET)-a compound inducing myelin vacuolization and brain oedema-with Ca(2+) homoeostasis and actin polymerization results in an adverse effect on ne...Continue Reading

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Citations

Feb 28, 2014·Cell Biology and Toxicology·Neelima Sharma, Anoop Kumar
Mar 6, 2009·Midwifery·Mary CarolanHeather Margetts
Jan 24, 2018·Frontiers in Endocrinology·Igor Ferraz da SilvaLívia Carla de Melo Rodrigues

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