PMID: 15157458Jun 1, 1996

Actin-related protein 1 and cytoplasmic dynein-based motility - what's the connection?

Trends in Cell Biology
T A SchroerS R Gill

Abstract

The actin-related protein Arp1 works in conjunction with the microtubule-based motor cytoplasmic dynein to drive many types of intracellular motility. In vertebrate cells, Arp1 is present exclusively in the form of a 37-nm filament that constitutes the backbone of dynactin, a 1.2-MDa macromolecular complex containing nine other polypeptides. Dynactin has been proposed to function as the link between dynein and its cargo. Recent work indicates that the dynactin subunit p150(Glued) mediates the interaction of the dynactin molecule with dynein and microtubules, leaving the Arp1 filament as a possible cargo-binding domain. Mechanisms for binding of F-actin to membranes are discussed as models of the Arp1-membrane interaction.

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Citations

Jul 25, 1998·Cell Motility and the Cytoskeleton·X WuJ A Hammer
Jul 6, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L A Boyer, C L Peterson
May 1, 1996·Trends in Cell Biology·J E Rickard, T E Kreis
Mar 4, 1998·Current Opinion in Cell Biology·N HirokawaY Okada
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·K EmotoM Umeda
Jul 16, 2008·Biochemistry. Biokhimii︠a︡·I B Alieva, R E Uzbekov
Mar 12, 2004·Annual Review of Plant Physiology and Plant Molecular Biology·Ben Scheres, Philip N. Benfey
Dec 28, 1999·Annual Review of Cell and Developmental Biology·D A Schafer, T A Schroer
Aug 31, 2000·Annual Review of Biochemistry·D A Compton
Jun 8, 2000·Microscopy Research and Technique·C Zeng
Jan 1, 1996·Cell Motility and the Cytoskeleton·M P Koonce
Jan 13, 1999·The Journal of Cell Biology·G S DiamantopoulosJ E Rickard
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Jun 26, 2002·The Journal of Biological Chemistry·Tianquan Jin, Jianxun Li
Aug 28, 1999·The Journal of Biological Chemistry·J ScheelT E Kreis
Oct 16, 2004·The Journal of Biological Chemistry·Jennifer M HarrellWilliam B Pratt

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