Actin shapes the autophagosome

Nature Cell Biology
Petter Holland, Anne Simonsen

Abstract

Compared with most intracellular vesicles, the autophagosome is formed by an unusual event of vesicle budding involving an elusive sequence of membrane expansions that ends with a double membrane vesicle. It is now shown that actin polymerization inside the forming autophagosome is a driving force for the expansion and assembly of a functional autophagosome.

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Citations

May 6, 2016·Traffic·Antonina J KruppaFolma Buss
Oct 30, 2016·Trends in Biochemical Sciences·Oren ShatzAnne Simonsen
Feb 9, 2019·PloS One·Marc BourouisPierre Leopold
Nov 28, 2019·Molecular & Cellular Proteomics : MCP·Stamatia RontogianniMaarten Altelaar
Sep 8, 2017·Diabetes, Obesity & Metabolism·Andreas MüllerMichele Solimena
Jul 9, 2016·FEBS Letters·Alf Håkon Lystad, Anne Simonsen
Jan 17, 2021·Molecular & Cellular Proteomics : MCP·Stamatia RontogianniMaarten Altelaar

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Related Concepts

Related Feeds

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

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