Actinometric and Φ-order photodegradation properties of anti-cancer Sunitinib

Journal of Pharmaceutical and Biomedical Analysis
Mounir Maafi, Lok Yan Lee

Abstract

The photodegradation reaction of Sunitinib (SUT), occurring via Z-E photoisomerisation, has been evaluated in this study using the recently developed Φ-order kinetics. In ethanol, the forward (Z → E) photoreaction of SUT was invariant with irradiation (its quantum yield, Φ(E-->Z)(λ)(irr) ≈ 0.019) in contrast to the E → Z isomerisation whose Φ(E-->Z)(λ)(irr) undergoes a 30-fold, sigmoid-shaped, increase with increasing irradiation wavelength. This situation limited usefully the extent of Z-SUT photodegradation at the photostationary state to a maximum of c.a. 30% of the initial concentration. Nevertheless, these results support a strong recommendation for a complete protection of SUT from light at all stages. Furthermore, a SUT-actinometer was developed and was proven to be useful for the 320-480 nm spectral range. The latter wavelength interval defined as well SUT photodegradation causative range. The formalism of Φ-order kinetics proves to be a useful investigative tool for drugs' photodegradation studies.

References

May 13, 2004·Journal of Pharmaceutical and Biomedical Analysis·Yeping ZhaoLida Antonian
Oct 1, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Patton MinkinSharyn D Baker
Jun 10, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·A HaoualaL A Decosterd
Oct 3, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Marie-Christine Etienne-GrimaldiGérard Milano
Dec 15, 2010·Journal of Pharmaceutical and Biomedical Analysis·Clayton Anderson de Azevedo FilhoBeate Saegesser Santos
Feb 11, 2011·The New England Journal of Medicine·Eric RaymondPhilippe Ruszniewski
Jul 13, 2011·Advanced Drug Delivery Reviews·Itsuro TomatsuAlexander Kros
Sep 20, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Benjamin M Wohl, Johan F J Engbersen
Mar 6, 2012·Advanced Drug Delivery Reviews·Nadezda FominaAdah Almutairi
Dec 13, 2012·Journal of Pharmaceutical Sciences·Katarzyna SidorykKrzysztof Woźniak
Aug 21, 2013·International Journal of Pharmaceutics·Wassila Maafi, Mounir Maafi
May 27, 2014·International Journal of Pharmaceutics·Mounir Maafi, Wassila Maafi

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Citations

Jul 16, 2015·Journal of Pharmaceutical Sciences·Mounir Maafi, Lok-Yan Lee
Oct 14, 2018·Biomedical Chromatography : BMC·Noriko MatsunagaHitoshi Sasaki

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