PMID: 5907287Feb 25, 1966

Actinomycin D: inhibition of respiration and glycolysis

Science
J LaszloP Hochstein

Abstract

Actinomycin D inhibited respiration and anaerobic glycolysis of human leukemic leukocytes and lowered the adenosine triphosphate content of the cells. Inhibitory effects on respiration and on RNA synthesis could not be dissociated from one another over a wide range of drug concentrations. Actinomycin D also impaired protein synthesis, probably by decreasing the availability of adenosine triphosphate and by inhibiting messenger RNA.

Citations

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Related Concepts

Adenosine Triphosphate, Chromium Ammonium Salt
Ac-De
Glycolysis
Leukemia
Leukocytes
Oxygen Consumption
RNA
Poly(A) Tail
Protein Biosynthesis

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