PMID: 5907287Feb 25, 1966

Actinomycin D: inhibition of respiration and glycolysis

J LaszloP Hochstein


Actinomycin D inhibited respiration and anaerobic glycolysis of human leukemic leukocytes and lowered the adenosine triphosphate content of the cells. Inhibitory effects on respiration and on RNA synthesis could not be dissociated from one another over a wide range of drug concentrations. Actinomycin D also impaired protein synthesis, probably by decreasing the availability of adenosine triphosphate and by inhibiting messenger RNA.


Aug 1, 1967·The Journal of Experimental Zoology·K V Prahlad, L E DeLanney
Oct 1, 1968·The Journal of Experimental Zoology·J R Whittaker
Jul 1, 1969·The Journal of Experimental Zoology·M Westin
Aug 1, 1974·The Journal of Experimental Zoology·H M Weitlauf
Jun 1, 1975·The Journal of Experimental Zoology·Y K TakeuchiT Kajishima
Feb 1, 1978·The Journal of Experimental Zoology·F J Longo
Feb 1, 1979·Developmental Biology·P R Braude
Jan 1, 1983·Developmental Biology·L CaseyA Jacobson
Dec 1, 1975·Experimental and Molecular Pathology·S N GiriP Bacchetti
Jul 15, 1967·Life Sciences·A K FieldA A Tytell
Jan 1, 1968·Currents in Modern Biology·A Dugaiczyk, J J Eiler
Jul 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·E B ThompsonJ F Curran
Jun 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·A D Deitch, G C Godman
Dec 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·B W O'Malley, P O Kohler
Aug 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·F C Kafatos, J Reich
Jan 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·P Gaskill, D Kabat
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M DeBernardi, G Brooker
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M Neeman, H Degani
Jan 1, 1969·The Journal of Cell Biology·J A Piper, N W Klein
Aug 1, 1969·The Journal of Cell Biology·G M Jagiello
Mar 11, 2005·Molecular Biology of the Cell·Yaron Shav-TalDov Zipori
Sep 1, 1967·Plant Physiology·R J Ellis, I R Macdonald
Mar 1, 1968·The Journal of Clinical Investigation·B W O'Malley, W L McGuire
Feb 7, 2013·Cellular and Molecular Life Sciences : CMLS·Frédérique NolinDominique Ploton
May 2, 1967·Biochimica Et Biophysica Acta·J T Holden, N M Utech
Oct 5, 1970·FEBS Letters·G E. Morris, A Korner
Jan 1, 1967·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J F Scaife, H Brohée
Apr 1, 1967·Experimental Cell Research·G M Donnelly, J E Sisken
Oct 1, 1967·Experimental Cell Research·E Eliasson
Dec 9, 1968·Biochemical and Biophysical Research Communications·P O KohlerP L Rayford
Oct 1, 1968·Experimental Cell Research·H W ChenP A Kitos
Aug 12, 1966·Biochemical and Biophysical Research Communications·R G Pannbacker, B E Wright
Aug 1, 1968·Archives of Biochemistry and Biophysics·L ProskyR L Imblum
Jun 1, 1967·Biochemical Pharmacology·N S Mizuno
Jun 1, 1974·Wilhelm Roux' Archiv Für Entwicklungsmechanik Der Organismen·Meredith Gould-Somero, Linda Holland

Related Concepts

Adenosine Triphosphate, Chromium Ammonium Salt
Oxygen Consumption
Poly(A) Tail
Protein Biosynthesis

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