Action mechanism of insulin-mimetic vanadyl-allixin complex

Chemistry & Biodiversity
Makoto Hiromura, Hiromu Sakurai

Abstract

In the 21st century, there has been a dramatic worldwide increase in the prevalence of metabolic syndromes, including diabetes mellitus (DM). Several synthetic pharmaceutical agents have been developed and used for the treatment of type-2 DM; however, these compounds have several problems such as side effects, hypoglycemia, and weight gain. Therefore, new drugs are required for DM therapy. We have proposed that some vanadyl complexes function as potent insulin-mimetic and antidiabetic agents in type-1 and type-2 DM animal models. In this article, we review the possible action mechanism of insulin-mimetic and antidiabetic vanadyl complexes, focusing on a recently proposed complex, bis(allixinato)oxovanadium(IV), with respect to the insulin-signaling pathway in cultured adipocytes.

References

Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E DegermanV C Manganiello
Jan 25, 2000·American Journal of Physiology. Endocrinology and Metabolism·T J Kieffer, J F Habener
May 3, 2000·The Journal of Clinical Investigation·M Aizawa-AbeK Nakao
Jan 18, 2002·Nature·Yasuhiko MinokoshiBarbara B Kahn
Feb 19, 2002·Trends in Cell Biology·Alan R Saltiel, Jeffrey E Pessin
Mar 26, 2002·Chemical & Pharmaceutical Bulletin·Yukihiro KoderaKazuhisa Ono
Jul 11, 2002·The Journal of Biological Chemistry·Daniel C BerwickJeremy M Tavare
May 8, 2004·Trends in Biochemical Sciences·Derek P BrazilBrian A Hemmings
Jan 27, 2005·Diabetes & Metabolism·C PosticJ Girard
Sep 27, 2005·Cellular Signalling·González-Yanes Carmen, Sánchez-Margalet Víctor
Nov 17, 2005·Oncogene·David R Plas, Craig B Thompson
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Cullen M TaniguchiC Ronald Kahn
Mar 1, 2006·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Kioumars A JelvehRoger W Brownsey
Apr 29, 2006·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Dominique Langin
May 19, 2006·Biochemical and Biophysical Research Communications·Yusuke AdachiHiromu Sakurai
Jul 11, 2006·American Journal of Physiology. Endocrinology and Metabolism·Nobuharu FujiiLaurie J Goodyear
Jul 11, 2006·The Journal of Clinical Investigation·Mark A Herman, Barbara B Kahn
Jul 11, 2006·The Journal of Clinical Investigation·Yun Chau Long, Juleen R Zierath
Sep 15, 2006·Biochemical and Biophysical Research Communications·Wanny BasukiHiromu Sakurai
Sep 7, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Makoto HiromuraHiromu Sakurai
Jun 1, 2007·Expert Opinion on Drug Discovery·Hiromu Sakurai

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Citations

May 22, 2020·Journal of Inorganic Biochemistry·Samuel Treviño, Alfonso Diaz
Mar 27, 2010·The Journal of Physical Chemistry. a·Birong ZengZhong Chen
Jul 16, 2010·Journal of Inorganic Biochemistry·Marta PassadouroM Margarida C A Castro

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