Action of 5-bromouracil and its nucleosides on the morphogenesis of the cuttings of etiolated tomato seedlings

Planta
A Guillot

Abstract

1. 5-Bromouracil inhibits the growth of the hypocotyl and the rhizogenesis in the cuttings of etiolated tomato seedlings only at high concentrations. 5-Bromouridine is inactive, but 5-bromodeoxyuridine strongly inhibits both phenomena. 2. The inhibition induced by 5-bromouracil cannot be reversed by thymine, deoxythymidine, uracil, uidine or β-alanine, a catabolic product of uracil. 3. Deoxythymidine is the one pyrimidine nucleoside which reverses the inhibition of growth and rhizogenesis brought about by 5-bromodeoxyuridine. 4. Deoxycytidine enhances the inhibition of rhizogenesis caused by 5-bromodeoxyuridine. Such an effect on the growth of the hypocotyl is not observed. 5. Taking into consideration the data in the literature, it is concluded: a)5-bromouracil can act in several ways which possibly differ according to the plant species: in some instances (as in the case described here), it seems to act by a mechanism unconnected with the metabolism of pyrimidine nucleic bases: b) 5-bromodeoxyuridine is a specific antimetabolite of deoxythymidine, but other metabolic interactions exist between 5-bromodeoxyuridine and deoxycytidine, each of the latter substances probably acting as a modifier of the metabolism of the other.

References

Jan 25, 1968·Biochemical and Biophysical Research Communications·J Doskocil, V Paces
May 1, 1968·Canadian Journal of Biochemistry·H L TarrM Yamamoto
Jun 28, 1967·Journal of Molecular Biology·W F Haut, J H Taylor
Aug 1, 1957·Biochimica Et Biophysica Acta·S GRISOLIA, S S CARDOSO
Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·Y HOTTA, H STERN
Jun 24, 1961·Biochimica Et Biophysica Acta·K SEBESTAZ SORMOVA
May 15, 1960·Experientia·Z SORMOVAF SORM
Apr 1, 1963·The Journal of Cell Biology·S T TAKATS, R M SMELLIE
Jan 1, 1963·Annual Review of Biochemistry·R W BROCKMAN, E P ANDERSON
Aug 13, 1962·Biochimica Et Biophysica Acta·P NEWMARKH W BARRETT
Mar 1, 1966·Planta·Y Hirono, G P Rédei

Related Concepts

Beta-Alanine
Antimetabolites
Bromodeoxyuridine
Bromouracil
Deoxycytidine
Literature
Metabolism
Morphogenesis
Nucleic Acids
Nucleosides

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