Action of almitrine bismesylate on ventilation-perfusion matching in cats and dogs with part of the lung hypoventilated

Clinical and Experimental Pharmacology & Physiology
R A WachG R Barer

Abstract

Ventilation to one lobe of lung was reduced in anaesthetized open-chest cats and dogs to simulate the ventilation/perfusion (V/Q) mismatching of chronic lung disease. Blood flow to this lobe fell less than ventilation; thus lobar V/Q diminished. In seven cats almitrine (0.5 mg/kg + 10 micrograms/kg per min, i.v.) caused a rise in pulmonary artery pressure (PPA), increased flow through the hypoventilated lobe in six out of seven cats and both increased or decreased lobar vascular resistance (PVR); the lobar V/Q ratio therefore fell. Arterial and lobar venous oxygen tension (PO2) fell. In five dogs almitrine caused a rise in PPA and PVR but lobar flow changes were variable. Arterial and lobar venous PO2 fell. With fixed ventilation, almitrine failed to improve V/Q matching; there was no improvement in gas exchange in the hypoventilated lobe. In eight dogs the hypoventilated lobe was perfused at constant flow with right atrial blood (i.e. while V/Q was held constant). Almitrine caused a rise in perfusion pressure, vasoconstriction, followed, in five out of eight dogs, by vasodilatation. In six similar cat preparations, vasoconstriction but not vasodilatation was clearly shown. In two cats dilatation after almitrine was demonstrate...Continue Reading

References

Sep 1, 1975·Respiration Physiology·P HowardI P Mungall
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Sep 1, 1972·Comparative and General Pharmacology·M MaranS Dikstein
Nov 1, 1970·The Journal of Physiology·G R BarerJ W Shaw
Jan 1, 1983·The Journal of General Virology·R HauptmannJ W Almond

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Citations

Nov 1, 1987·Clinical and Experimental Pharmacology & Physiology·C A AustinG R Barer
Feb 3, 2012·Physiological Reviews·J T SylvesterJeremy P T Ward

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