PMID: 6974244Jan 1, 1981Paper

Action of caerulein, gastrin 17, pentagastrin, and secretin on the active transport of sodium by the frog skin

The Journal of Membrane Biology
J R Greenwell, H S Low

Abstract

Frog skin was mounted in an Ussing chamber and the actions of caerulein, gastrin, pentagastrin, and secretin on the active transport of sodium were studied using the short-circuit current method. All polypeptides exerted their effect when placed in the solution bathing the outside surface of the skin. The response was a transient dose-related increase in the transepithelial electrical potential difference and in the short-circuit current. Analysis of the response indicated that at submaximal doses the effect was due to an increase in the rate of entry of sodium through the outer barrier to active sodium transport. At supramaximal doses the passive permeability of the skin was also increased. Th ED50 concentrations of the hormones were: caerulein, 50 pM; gastrin, 53 pM; pentagastrin, 440 pM; and secretin, 30 pM. It is argued that the large quantity of caerulein or caerulein-like peptides stored in the skin may be required either to control the entry of sodium when the amphibian is undergoing maximum stress in a freshwater environment, or that it may have a protective function for the amphibian as it could elicit a noxious hypersecretion in the gastrointestinal tract of the predator together with a marked hypotension.

References

Apr 1, 1977·The Journal of Cell Biology·J W MillsD R DiBona
Sep 1, 1978·The American Journal of Physiology·K M BaldwinR E Lewis
May 1, 1977·The Journal of General Physiology·S I Helman, R S Fisher
Dec 1, 1976·The American Journal of Physiology·L J Cruz, T U Biber
Mar 1, 1975·The Journal of Cell Biology·G J Dockray, C R Hopkins
Aug 1, 1970·The Journal of Physiology·C R House
Jul 1, 1970·The Journal of General Physiology·T U Biber, P F Curran
Apr 11, 1968·The American Journal of Physiology·J G Dobson, G W Kidder
Apr 1, 1968·Archives of Biochemistry and Biophysics·A AnastasiR Endean
Sep 15, 1967·Experientia·V ErspamerM Impicciatore
Jun 2, 1958·Acta Physiologica Scandinavica·V KOEFOED-JOHNSEN, H H USSING
Oct 1, 1964·The American Journal of Physiology·G W KIDDERP F CURRAN
Mar 1, 1965·The Journal of General Physiology·M CEREIJIDO, P F CURRAN
Dec 1, 1971·The Journal of Membrane Biology·J Yonath, M M Civan

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Citations

Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·N PrimorJ N Forrest
Sep 3, 2017·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jamal NourinezhadYazdan Mazaheri
May 1, 1985·Biulleten' eksperimental'noĭ biologii i meditsiny·V A PshenichnovE P Efimova
Jan 1, 1984·Critical Reviews in Microbiology·V M Reusch
Jan 1, 1987·Critical Reviews in Microbiology·R J Doyle, A L Koch

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