PMID: 9162932Jan 1, 1997Paper

Action of dissolved ozone on mycobacterium tuberculosis and alveolar macrophages in experimental tuberculosis

Problemy tuberkuleza
I I BelianinL P Martynova

Abstract

Sixty CBA mice were intravenously inoculated with the Mycobacterium tuberculosis (MBT) strains Erdman and 2255 (a polyresistant clinical strain) pretreated with dissolved ozone (experimental groups), a single therapeutical dose. of dissolved ozone being intravenously injected. By 1 month of inoculation, all control mice (MBT-inoculated and ozone-untreated) died and in their organs there were a great deal of MBT both outside and inside the macrophages. No pathogen in its typical form was not found in experimental mice, but there were many granular and L forms, the lung showing a large number of highly vacuolized (foamy) alveolar macrophages (AM). All experimental mice survived by month 5 and their organ examination showed that the pathogen was detectable only inside the macrophages, but they are chiefly unchanged (more elongated and badly stained with aniline dyes). Juvenile forms are prevalent among AM. It should be concluded that the action of dissolved ozone on AM and MBT is heterodirectional.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.