Action of Dracocephalum argunense on mast cell-mediated allergy model

Biological & Pharmaceutical Bulletin
S H KimTae-Yong Shin

Abstract

The discovery of drugs for the treatment of allergic disease is an important subject in human health. Stimulation of mast cells starts the process of degranulation resulting in releasing of mediators, such as histamine. In this report, we investigated the effect of aqueous extract of Dracocephalum argunense Fisch. (Labiatae) (DAAE) on the mast cell-mediated allergic response and studied its possible mechanisms of action, focusing on the histamine release and pro-inflammatory cytokine secretion in mast cells. DAAE inhibited compound 48/80-induced systemic reactions and serum histamine release in mice. In addition, DAAE attenuated IgE-mediated skin allergic reaction. DAAE dose-dependently reduced IgE-induced histamine release from mast cells. The level of cAMP was transiently increased by treatment of DAAE. DAAE specifically blocked the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-induced p38 mitogen-activated protein kinase (MAPK) activation. DAAE decreased the secretion of pro-inflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-6 in mast cells. Our findings provide evidence that DAAE inhibits mast cell derived allergic reactions, and involvement of cAMP for histamine release and p3...Continue Reading

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Citations

Jul 3, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sang-Hyun KimTae-Yong Shin
Dec 8, 2011·Journal of Immunotoxicology·Savita D PatilSanjay J Surana
Aug 24, 2010·Chemistry & Biodiversity·Qi ZengWei-Dong Zhang
Jul 6, 2019·Frontiers in Pharmacology·Lee Yen SimKhairana Husain

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