PMID: 6412426Jun 1, 1983Paper

Action of EDTA-Tris and antimicrobial agent combinations on selected pathogenic bacteria

Veterinary Microbiology
R E Wooley, M S Jones

Abstract

The concentration of EDTA-Tris (3.22 mM EDTA and 0.05 M Tris) used as a lavage to treat otitis externa, cystitis or other persistent infections in dogs and cats, was found to prevent the growth of Pseudomonas aeruginosa, Staphylococcus aureus and beta streptococci when present in growth media. Pseudomonas aeruginosa was rapidly lysed in this solution. Escherichia coli and Proteus vulgaris grew in the presence of EDTA-Tris, but to a lesser extent than the controls without these compounds. Minimal inhibitory concentrations (MIC) for 8 antimicrobial agents with and without EDTA-Tris were determined for E. coli and P. vulgaris. A potentiation effect on E. coli (greater than 50% decrease MIC) was observed when EDTA-Tris was combined with penicillin, oxytetracycline or chloramphenicol. A similar effect was observed with P. vulgaris when combinations of EDTA-Tris plus gentamicin, oxytetracycline, polymyxin-B or triple sulfa were used. The results of this study indicate that EDTA-Tris appears to have merit in selected cases of otitis externa, cystitis or other persistent infections where lavage might be used.

References

Jun 1, 1977·Journal of Bacteriology·M E Bayer, L Leive
Jun 1, 1972·The Journal of Urology·M C GoldschmidtD E Johnson
Feb 1, 1968·Journal of Bacteriology·J R De Zeeuw
Jun 1, 1967·Journal of General Microbiology·M C Goldschmidt, O Wyss

❮ Previous
Next ❯

Citations

Dec 1, 1984·Veterinary Microbiology·R E WooleyE B Shotts
Jun 1, 1986·Veterinary Microbiology·R E WooleyJ Brown
Dec 31, 2011·Biomicrofluidics·Dietmar Puchberger-EnenglGerald A Urban
May 21, 2014·Biochimica Et Biophysica Acta·William F WalkenhorstJoshua M Laviolette
Nov 23, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Razan HamoudMichael Wink
Jan 12, 2016·Biochimica Et Biophysica Acta·William F Walkenhorst
Jun 3, 2009·Journal of Applied Microbiology·R S PercivalP D Marsh
Jul 16, 2010·Reproduction in Domestic Animals = Zuchthygiene·M M LeBlanc
Jul 15, 2015·Advances in Wound Care·Simon Finnegan, Steven L Percival
Oct 18, 2016·The Journal of Small Animal Practice·S Paterson
Jul 28, 2020·The Journal of Small Animal Practice·J M Fregeneda-GrandesA Carvajal-Urueña
Apr 17, 2021·Applied Microbiology and Biotechnology·Diksha RainaInshad Ali Khan
Jun 15, 2021·Drug Delivery and Translational Research·Shu-Wei HuangYi-Tzu Lee
Feb 11, 2004·The Veterinary Clinics of North America. Exotic Animal Practice·Branson W RitchieDouglas T Kemp
Dec 12, 2018·ACS Applied Materials & Interfaces·Debirupa MitraKoon Gee Neoh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.