PMID: 9437713Jan 1, 1997Paper

Action of FMRFamide-like peptides on porcine gastrointestinal motility in vitro

Peptides
B DeckerK Mandrek

Abstract

Mechanical activity was recorded in circular and longitudinal smooth muscle preparations isolated from extensive regions of the porcine gastrointestinal tract in response to the FMRFamide-like neuropeptides F8Famide and A18Famide. In all preparations, the peptides were about equipotent in producing phasic contractions or enhancing spontaneous activity. The most prominent responses were observed in jejunal longitudinal strips which were on the average 91% (+/- 4% SEM, n = 15; 10(-6) M) of the histamine (10(-5) M) responses. The peptide-induced phasic activity was completely abolished by nifedipine but was unaffected by tetrodotoxin, atropine, phentolamine, yohimbine, phenoxybenzamine, propranolol, methysergide, cimetidine, indomethacin, levallorphane or naloxone. Both peptides enhanced acetylcholine-induced contractions. However, bovine ileum and guinea-pig taenia coli was not affected by these peptides. The results indicate that F8F- and A18F-amide contract porcine gastrointestinal smooth muscle by acting directly via non-opioid receptors on L-type calcium channels. In addition an increase of the sensitivity to cholinergic stimulation occurs.

References

Aug 12, 1977·Science·D A Price, M J Greenberg
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Citations

Nov 26, 2010·Invertebrate Neuroscience : in·Stefanie SeippThomas Leitz
Apr 27, 2002·Micron : the International Research and Review Journal for Microscopy·C A NevesL B Gitirana
Nov 24, 2011·World Journal of Gastroenterology : WJG·Krishan KumarSantosh Pasha
Feb 21, 2006·Peptides·Flavie KersantéMichel Roumy
Dec 13, 2005·Journal of Neurochemistry·Minna-Liisa Ankö, Pertti Panula
Mar 10, 2009·Hormones and Behavior·Miklós JászberényiGyula Telegdy
Apr 14, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Biao XuQuan Fang
Dec 2, 2020·International Journal of Molecular Sciences·Piotr WojciechowskiKatarzyna Kaczyńska
May 24, 2021·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Mark BohlerMark A Cline

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