PMID: 6955798Jul 1, 1982Paper

Action of food restriction in delaying the aging process

Proceedings of the National Academy of Sciences of the United States of America
E J MasoroH A Bertrand


Food restriction has long been known to prolong life in rodents, and recent studies have shown it to have antiaging effects in regard to a variety of physiologic and pathologic processes. It has been suggested that these actions of food restriction relate to the reduction of metabolic rate per unit of body mass brought about by this dietary regimen. Data are presented in this report showing that food restriction can have a marked life-prolonging action in rats without reducing caloric intake per gram of body weight. Moreover, the food-restricted rats consumed a greater number of calories per gram of body weight during their lifetimes than did the rats fed ad lib, yet they lived longer. Thus, the data in this report do not support the concept that food restriction slows the rate of aging by decreasing the metabolic rate.


Sep 1, 1989·Aging : Clinical and Experimental Research·R J McCarterJ R McGee
Jun 1, 1991·Aging : Clinical and Experimental Research·E J Masoro, R J McCarter
Dec 1, 1991·Aging : Clinical and Experimental Research·E J Masoro
Dec 1, 1991·Aging : Clinical and Experimental Research·R J McCarter
Jun 1, 1993·Aging : Clinical and Experimental Research·B P Yu
Dec 8, 2005·Biogerontology·S Jay Olshansky, Suresh I S Rattan
Jan 1, 2000·Journal of the American Aging Association·J A MattisonA Bartke
Sep 1, 1991·Mutation Research·M G Simic, D S Bergtold
Jan 1, 1984·Mechanisms of Ageing and Development·B P YuE J Masoro
May 31, 1985·Mechanisms of Ageing and Development·J R Totter
Feb 1, 1986·Mechanisms of Ageing and Development·H Ooka, T Shinkai
Nov 1, 1987·Mechanisms of Ageing and Development·C B Olson
Jun 14, 1991·Mechanisms of Ageing and Development·H E EnescoB P Yu
Mar 1, 1995·Mechanisms of Ageing and Development·G M Gilad, V H Gilad
Mar 1, 1994·Mechanisms of Ageing and Development·S B HarrisR L Walford
Jul 17, 1996·Mechanisms of Ageing and Development·W MlekuschG Reibnegger
Mar 1, 1991·Archives of Gerontology and Geriatrics·C PieriF Marcheselli
Jan 1, 1991·Neurobiology of Aging·M T TacconiS Algeri
Nov 1, 1992·Comparative Biochemistry and Physiology. Comparative Physiology·C PieriF Marcheselli
Apr 1, 1995·Progress in Neurobiology·L Larsson, T Ansved
May 1, 1995·Experimental Gerontology·E J Masoro
Jan 1, 1996·Free Radical Biology & Medicine·B P Yu
Sep 1, 1992·Mutation Research·D Harman
May 12, 2005·Mechanisms of Ageing and Development·Edward J Masoro
Jun 9, 2005·Mechanisms of Ageing and Development·Leonard Guarente
May 18, 2005·Mechanisms of Ageing and Development·Glenda WalkerDavid Gems
Jun 7, 2005·Mechanisms of Ageing and Development·Linda PartridgeWilliam Mair
Jun 14, 2005·Medical Hypotheses·Thijs R Klompmaker
Apr 27, 2001·Mechanisms of Ageing and Development·K MerkerT Grune
Mar 9, 2000·Mechanisms of Ageing and Development·J A Greenberg, C N Boozer
Oct 24, 2002·Neurobiology of Aging·Gemma CasadesusJames A Joseph
Oct 28, 1999·Neurobiology of Aging·T D PughR Weindruch
Jan 19, 2000·Neurobiology of Aging·J R Vanfleteren, B P Braeckman
Feb 13, 2001·Experimental Gerontology·W A Van Voorhies

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