Action of histamine receptor agonists and antagonists on the rat uterus

British Journal of Pharmacology
G BertacciniL Zappia


1 Histamine and a series of compounds acting selectively on H1- and H2-receptors were tested on the isolated oestrous uterus of the rat. 2 Histamine had a dose-dependent inhibitory effect on the contractions elicited by acetylcholine. This action was unaffected by H1-blockers but was competitively inhibited by H2-blockers. The H1-selective agonist, 2-(2-aminoethyl)thiazole was ineffective at doses 100 times greater than those of histamine. Conversely, all the H2-agonists showed activity in the order of potency: N'-methylhistamine greater than histamine greater than N'-N'-dimethylhistamine greater than 5-methylhistamine greater than 5-methyl-N'-methylhistamine. Among the non-imidazole compounds, dimaprit had an activity identical to that of histamine, but all the dimaprit-like compounds showed negligible activity. 3 The data obtained suggest that in the rat uterus, (a) the activation of H2-receptors is responsible for the inhibitory effect of histamine and its analogues; (b) the integrity of the histamine molecule seems to be less crucial than that of the dimaprit molecule for the maintenance of the H2-activity, since changes in its structure modify but do not abolish the biological activity as they do in the case of dimaprit; (...Continue Reading


Feb 1, 1976·The Journal of Physiology·P Holton, J Spencer
Jul 1, 1976·Journal of Medicinal Chemistry·G J DurantR A Slater
Jan 1, 1978·Advances in Experimental Medicine and Biology·G Bertaccini
Sep 1, 1975·Journal of Medicinal Chemistry·G J DurantM E Parsons
Sep 1, 1978·Pharmacological Research Communications·G BertacciniT Vitali
Apr 21, 1972·Nature·J W BlackE M Parsons
Sep 1, 1971·The Journal of Physiology·C F CodeH Navert
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD
Jan 1, 1961·Acta Pharmacologica Et Toxicologica·K B JENSEN, A M VENNEROD
Sep 1, 1949·British Journal of Pharmacology and Chemotherapy·H O SCHILD


Nov 1, 1986·Agents and Actions·G BertacciniM Adami
Feb 5, 1982·European Journal of Pharmacology·R K Goyal, S C Verma
Jan 13, 1984·European Journal of Pharmacology·J CortijoE Rubio
Jun 1, 1994·Respiration Physiology·K YamadaT Takishima
Jun 1, 1997·Journal of Veterinary Pharmacology and Therapeutics·T KitazawaT Taneike
Nov 1, 1984·Pharmacological Research Communications·E PoliG Bertaccini
Mar 1, 1989·The Journal of Pharmacy and Pharmacology·S E Ohia, A A Laniyonu
Feb 1, 1981·British Journal of Pharmacology·G Bertaccini, G Coruzzi
Feb 14, 2015·Journal of Ethnopharmacology·Tariro MawozaCharles Nhachi
Oct 13, 2005·Phytotherapy Research : PTR·Muhammad Nabeel Ghayur, Anwarul Hassan Gilani
Jan 1, 1993·The American Review of Respiratory Disease·K SekizawaT Takishima

Related Concepts

Antihistamines, Classical
Histamine H2 Antagonists
Histamine Receptor
Uterine Contraction
Rats, Laboratory
In Vitro [Publication Type]

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.