Action of in situ nitroglycerin on upper anal canal pressure of patients with terminal constipation. A pilot study

Diseases of the Colon and Rectum
F GuillemotA Cortot

Abstract

Nitroglycerin (NTG) in situ reduces the pressure of the upper anal sphincter (UAS). We have tested the effects of NTG on the UAS of patients with terminal constipation. We studied two groups of constipated patients. Group 1 consisted of 11 patients (nine females and two males) with hypertonicity of the UAS (> 70 mm Hg); age was 49.5 +/- 15.6 years. Group 2 consisted of 10 patients (nine females and one male) without hypertonicity; age was 40.1 +/- 14.1 years. Group 3 consisted of eight asymptomatic controls (four females and four males); age was 51.7 +/- 6.9 years. After a 10-minute resting pressure recording of the UAS with a water-filled balloon, the probe was pulled through the outside and the UAS was assessed after spreading 5 mg of placebo and then 5 mg of NTG on the balloon. Resting pressure (RP), delay of the pressure decrease (DP), pressure after five minutes either during the NTG (PN5) or placebo (PP5) period, and mean duration of the pressure decrease (MD) were measured. None of the subjects experienced a decrease of PP5 vs. RP. All patients in Group 1 (106.2 vs. 38.4 mm Hg), Group 2 (57.9 vs. 31.4 mm Hg), and controls (62.2 vs. 33.7 mm Hg) experienced a significant decrease of pressure of the UAS (P < 0.005). Delay o...Continue Reading

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Citations

Jul 1, 1996·Diseases of the Colon and Rectum·U C ParkS D Wexner
Jul 1, 1997·Diseases of the Colon and Rectum·H BacherW Schweiger
May 1, 1995·Diseases of the Colon and Rectum·S R Gorfine
Jun 23, 1999·Diseases of the Colon and Rectum·T A CookN J Mortensen
Aug 7, 2007·Techniques in Coloproctology·E E Collins, J N Lund
Mar 29, 2005·Diseases of the Colon and Rectum·M J ThorntonD W King
Sep 3, 1998·Alimentary Pharmacology & Therapeutics·L SiproudhisM Gosselin
Jun 26, 2001·Alimentary Pharmacology & Therapeutics·T A CookN J Mortensen
Nov 28, 2001·Postgraduate Medical Journal·K McCallion, K R Gardiner
Nov 15, 2006·World Journal of Surgery·Abraham A Ayantunde, Samuel A Debrah
May 17, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J J TjandraD Z Lubowski
Jul 1, 2000·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland· Zbar Guillou
Oct 1, 1996·The British Journal of Surgery·J N Lund, J H Scholefield
Sep 28, 2002·Diseases of the Colon and Rectum·H Randolph BaileyUNKNOWN Fissure Study Group

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