Action of iron chelator on intramyocardial hemorrhage and cardiac remodeling following acute myocardial infarction

Basic Research in Cardiology
Bita BehrouziNilesh R Ghugre

Abstract

Intramyocardial hemorrhage is an independent predictor of adverse outcomes in ST-segment elevation myocardial infarction (STEMI). Iron deposition resulting from ischemia-reperfusion injury (I/R) is pro-inflammatory and has been associated with adverse remodeling. The role of iron chelation in hemorrhagic acute myocardial infarction (AMI) has never been explored. The purpose of this study was to investigate the cardioprotection offered by the iron-chelating agent deferiprone (DFP) in a porcine AMI model by evaluating hemorrhage neutralization and subsequent cardiac remodeling. Two groups of animals underwent a reperfused AMI procedure: control and DFP treated (N = 7 each). A comprehensive MRI examination was performed in healthy state and up to week 4 post-AMI, followed by histological assessment. Infarct size was not significantly different between the two groups; however, the DFP group demonstrated earlier resolution of hemorrhage (by T2* imaging) and edema (by T2 imaging). Additionally, ventricular enlargement and myocardial hypertrophy (wall thickness and mass) were significantly smaller with DFP, suggesting reduced adverse remodeling, compared to control. The histologic results were consistent with the MRI findings. To date...Continue Reading

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Citations

Feb 7, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ning LiQing Geng
Jul 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yuhan QinGaoliang Yan
Jul 16, 2021·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Xingmin GuanRohan Dharmakumar
Aug 10, 2021·JACC. Basic to Translational Science·Javier InserteIgnacio Ferreira-González
Aug 10, 2021·Frontiers in Cardiovascular Medicine·Huilin HuLiang Shen
Aug 21, 2021·Frontiers in Physiology·Degang ChengChengzhi Lu

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