Action of obestatin in skeletal muscle repair: stem cell expansion, muscle growth, and microenvironment remodeling

Molecular Therapy : the Journal of the American Society of Gene Therapy
Uxía Gurriarán-RodríguezJesús P Camiña

Abstract

The development of therapeutic strategies for skeletal muscle diseases, such as physical injuries and myopathies, depends on the knowledge of regulatory signals that control the myogenic process. The obestatin/GPR39 system operates as an autocrine signal in the regulation of skeletal myogenesis. Using a mouse model of skeletal muscle regeneration after injury and several cellular strategies, we explored the potential use of obestatin as a therapeutic agent for the treatment of trauma-induced muscle injuries. Our results evidenced that the overexpression of the preproghrelin, and thus obestatin, and GPR39 in skeletal muscle increased regeneration after muscle injury. More importantly, the intramuscular injection of obestatin significantly enhanced muscle regeneration by simulating satellite stem cell expansion as well as myofiber hypertrophy through a kinase hierarchy. Added to the myogenic action, the obestatin administration resulted in an increased expression of vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor 2 (VEGFR2) and the consequent microvascularization, with no effect on collagen deposition in skeletal muscle. Furthermore, the potential inhibition of myostatin during obestatin trea...Continue Reading

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Citations

Oct 13, 2016·The American Journal of Sports Medicine·Angela ZisslerAlexandra M Sänger
Jul 5, 2017·Journal of Cachexia, Sarcopenia and Muscle·Tania Cid-DíazJesús P Camiña
Feb 22, 2018·Journal of Animal Physiology and Animal Nutrition·M SzlisA Wójcik-Gładysz
Sep 15, 2018·Journal of Cachexia, Sarcopenia and Muscle·Jessica González-SánchezJesús P Camiña
Oct 1, 2019·Anatomia, histologia, embryologia·Hakan SağsözBerna Güney Saruhan
Oct 16, 2018·Frontiers in Physiology·Alessandra RenziniSergio Adamo
May 20, 2017·Scientific Reports·Icía Santos-ZasJesus P Camiña
Feb 24, 2018·Scientific Reports·Nicoletta MarroncelliViviana Moresi
Apr 3, 2019·International Journal of Molecular Sciences·Agnieszka StempniewiczZygmunt Warzecha
Jan 6, 2021·Cellular and Molecular Neurobiology·Agustín Sánchez-TempranoYolanda Pazos
Dec 11, 2020·International Journal of Molecular Sciences·Georgios KallifatidisBal L Lokeshwar
Mar 10, 2021·Journal of Cachexia, Sarcopenia and Muscle·Tania Cid-DíazJesus P Camiña
Jan 27, 2020·Theriogenology·Michał SzlisBartosz Jarosław Przybył

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