PMID: 6968593Sep 9, 1980Paper

Action of oxidized and reduced glutathione on rabbit red blood cell hexokinase

Biochimica Et Biophysica Acta
M MagnaniG Fornaini

Abstract

Reduced glutathione at 1 mM concentration is able to mantain rabbit red blood cell hexokinase (EC 2.7.1.1) in the reduced state with fully catalytic activity. At higher concentrations a marked inhibition is observed. In contrast, oxidized glutathione is a strong inhibitor of reduced erythrocyte hexokinase at all the concentration studied. Inactivation experiments show that some sulfhydryl groups reacting with oxidized glutathione are responsible for the enzyme inactivations. These findings suggest a cellular inter-relationship between redox and energetic metabolism coupled through glutathione at the hexokinase level.

References

Aug 1, 1979·Archives of Biochemistry and Biophysics·G K Smith, S W Schaffer
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Feb 18, 1964·Biochemical and Biophysical Research Communications·I A RoseE L O'Connell
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Citations

Oct 1, 1979·Mechanisms of Ageing and Development·M MagnaniG Fornaini
Mar 1, 1982·Mechanisms of Ageing and Development·M MagnaniG Fornaini
Jul 1, 1983·Mechanisms of Ageing and Development·M MagnaniG Fornaini
Jan 1, 1990·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M Kaloyianni, M Kalomenopoulou
Nov 25, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·L CanesiG Gallo
Jun 14, 2000·Experimental Eye Research·F QiaoM F Lou
Jan 1, 1984·Archives of Biochemistry and Biophysics·M C PintoJ Lopez-Barea
Jun 19, 1984·Biochimica Et Biophysica Acta·M MagnaniG Fornaini
Jan 1, 1986·Japanese Journal of Pharmacology·M TsujitaniH Ito

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